比丝勒酮 A，一种来自 Griffith 山白树 Leuconotis griffithii 的 eburnane-阿皮斯多培曼双吲哚生物碱。
Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii.
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
出版信息
Bioorg Med Chem Lett. 2010 Mar 15;20(6):2021-4. doi: 10.1016/j.bmcl.2010.01.051. Epub 2010 Jan 20.
PMID:20153644
Abstract
A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines.
摘要
从 Griffith 勒乌寇属植物树皮中分离得到一个新的双吲哚生物碱，双勒乌寇宁 A（1），由一个鹅掌楸-阿朴菲型骨架组成。基于二维 NMR 数据和 X 射线分析阐明了其结构包括绝对立体化学。双勒乌寇宁 A（1）对各种人癌细胞系表现出细胞生长抑制活性。
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