Department of Sexual Health and HIV Medicine, Directorate of Infection, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, University of Birmingham, Birmingham, UK.
Curr Opin HIV AIDS. 2010 Jul;5(4):335-43. doi: 10.1097/COH.0b013e32833a0b69.
To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract.
Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentrations achieved vary considerably depending on the class of drug studied, the sampling techniques used and the times samples are obtained.
There appear to be several patterns of drug penetration into the male and female genital tract. In addition there appear to be different patterns of genital shedding under the influence of antiretroviral therapy. What effect these factors will have on the sexual transmission of HIV or the evolution and transmission of resistant HIV remains to be seen.
总结 2008 至 2010 年间抗逆转录病毒（ARV）药物在男性和女性生殖道中处置的最新文献。
最近的研究证实，抗逆转录病毒药物渗透到男性和女性生殖道均具有药物和性别特异性。所达到的浓度差异很大，这取决于所研究的药物类别、所用的采样技术以及获得样本的时间。
药物似乎有几种渗透到男性和女性生殖道的模式。此外，在抗逆转录病毒治疗的影响下，生殖器脱落也似乎存在不同的模式。这些因素对 HIV 的性传播或耐药性 HIV 的演变和传播将产生何种影响仍有待观察。
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