Sokolova N A, Ashmarin I P
Nauchnye Doki Vyss Shkoly Biol Nauki. 1991(1):102-6.
On the isolated frog heart alpha- and gamma-endorphins depressed the chronotropic effects of exogenous acetylcholine. Naloxone partially blocked the atropine-like action of alpha-, gamma-endorphins. The latent period of the reaction to the endorphin injection was about 20 min, the endorphin effect retained more than 1 h. The obtained data show that some opioids may act as "endogenous atropine".
在离体蛙心上，α-内啡肽和γ-内啡肽可抑制外源性乙酰胆碱的变时作用。纳洛酮可部分阻断α-、γ-内啡肽的类阿托品作用。注射内啡肽后反应的潜伏期约为20分钟，内啡肽的作用可持续1小时以上。所得数据表明，某些阿片类物质可能起“内源性阿托品”的作用。
