Institute of Biological Sciences (Division of Genetics and Molecular Biology), Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Curr Microbiol. 2011 Jan;62(1):167-72. doi: 10.1007/s00284-010-9689-z. Epub 2010 Jun 11.
Bacterial quorum sensing signal molecules called N-acylhomoserine lactone (AHL) controls the expression of virulence determinants in many Gram-negative bacteria. We determined AHL production in 22 Aeromonas strains isolated from various infected sites from patients (bile, blood, peritoneal fluid, pus, stool and urine). All isolates produced the two principal AHLs, N-butanoylhomoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). Ten isolates also produced additional AHLs. This report is the first documentation of Aeromonas sobria producing C6-HSL and two additional AHLs with N-acyl side chain longer than C(6). Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen.
细菌群体感应信号分子称为 N-酰基高丝氨酸内酯（AHL）控制许多革兰氏阴性细菌毒力决定因素的表达。我们从患者不同感染部位（胆汁、血液、腹腔液、脓液、粪便和尿液）分离的 22 株气单胞菌中确定了 AHL 的产生。所有分离株均产生两种主要的 AHL，N-丁酰高丝氨酸内酯（C4-HSL）和 N-己酰高丝氨酸内酯（C6-HSL）。10 个分离株还产生了其他 AHL。本报告首次记录了产碱气单胞菌产生 C6-HSL 和另外两种具有比 C（6）更长的 N-酰基侧链的 AHL。我们的数据提供了对这种环境细菌作为人类病原体出现的机制的更好理解。
