National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Magn Reson Med. 2010 Sep;64(3):787-98. doi: 10.1002/mrm.22461.
The purpose of this study is to develop and evaluate a displacement-encoded pulse sequence for simultaneous perfusion and strain imaging. Displacement-encoded images in two to three myocardial slices were repeatedly acquired using a single-shot pulse sequence for 3 to 4 min, which covers a bolus infusion of Gadolinium contrast. The magnitudes of the images were T(1) weighted and provided quantitative measures of perfusion, while the phase maps yielded strain measurements. In an acute coronary occlusion swine protocol (n = 9), segmental perfusion measurements were validated against microsphere reference standard with a linear regression (slope 0.986, R(2) = 0.765, Bland-Altman standard deviation = 0.15 mL/min/g). In a group of ST-elevation myocardial infarction patients (n = 11), the scan success rate was 76%. Short-term contrast washout rate and perfusion are highly correlated (R(2) = 0.72), and the pixelwise relationship between circumferential strain and perfusion was better described with a sigmoidal Hill curve than linear functions. This study demonstrates the feasibility of measuring strain and perfusion from a single set of images.
本研究旨在开发和评估一种用于同时进行灌注和应变成像的位移编码脉冲序列。使用单次激发脉冲序列重复采集两到三个心肌切片的位移编码图像，持续 3 到 4 分钟，覆盖钆对比剂的团注。图像的幅度为 T1 加权，提供灌注的定量测量值，而相位图则提供应变测量值。在急性冠状动脉闭塞猪模型中（n=9），通过线性回归（斜率 0.986，R²=0.765，Bland-Altman 标准差=0.15 mL/min/g）对节段性灌注测量值与微球参考标准进行了验证。在一组 ST 段抬高型心肌梗死患者中（n=11），扫描成功率为 76%。短期对比洗脱率和灌注高度相关（R²=0.72），圆周应变和灌注之间的像素关系用 Sigmoid Hill 曲线描述比线性函数更好。本研究证明了从一组图像中测量应变和灌注的可行性。
