Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom.
Mov Disord. 2010 Jul 30;25(10):1343-9. doi: 10.1002/mds.22692.
Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression.
学习可以在有意识或无意识的情况下发生，也可以是外显（有意的）或内隐（偶然的）学习。尾状核和壳核在亨廷顿病（HD）早期受到影响，被认为对运动序列学习至关重要。然而，现有的研究结果在 HD 中内隐和外显运动序列学习是否存在缺陷方面并不一致。我们使用具有相同结构的序列在 15 名具有阳性 HD 遗传测试的个体（7 名前显型；8 名早期疾病）和 11 名匹配的对照组中评估了内隐和外显运动序列学习。HD 组表现出正常的内隐运动序列学习的证据，而外显运动序列学习在显型和前显型 HD 基因携带者中受损，随着疾病的进展而逐渐下降。外显序列学习可能是 HD 进展的有用认知生物标志物。
