瞬时受体电位阳离子通道 M 型 1（TRPM1）：视网膜光感受器双极细胞中 mGluR6 信号转导级联的终点。
TRPM1: the endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells.
机构信息
Oregon Health and Science University, Ophthalmology, Portland, Oregon, USA.
出版信息
Bioessays. 2010 Jul;32(7):609-14. doi: 10.1002/bies.200900198.
Abstract
For almost 30 years the ion channel that initiates the ON visual pathway in vertebrate vision has remained elusive. Recent findings now indicate that the pathway, which begins with unbinding of glutamate from the metabotropic glutamate receptor 6 (mGluR6), ends with the opening of the transient receptor potential (TRP)M1 cation channel. As a component of the mGluR6 signal transduction pathway, mutations in TRPM1 would be expected to cause congenital stationary night blindness (CSNB), and several such mutations have already been identified in CSNB families. Furthermore, expression of TRPM1 in both the retina and skin raises the possibility that a genetic link exists between certain types of visual and skin disorders.
摘要
近 30 年来，脊椎动物视觉中启动光感受器信号转导的离子通道一直难以捉摸。最近的研究结果表明，该通路始于代谢型谷氨酸受体 6（mGluR6）与谷氨酸的解离，最终导致瞬时受体电位（TRP）M1 阳离子通道的开放。作为 mGluR6 信号转导通路的一个组成部分，TRPM1 的突变预计会导致先天性静止性夜盲症（CSNB），并且已经在 CSNB 家族中发现了几种这样的突变。此外，TRPM1 在视网膜和皮肤中的表达增加了某些类型的视觉和皮肤疾病之间存在遗传联系的可能性。
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本文引用的文献
1
2
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.瞬时受体电位阳离子通道亚家族 M 成员 1（TRPM1）是 mGluR6 级联中视网膜 ON 双极细胞转导通道的一个组成部分。
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):332-7. doi: 10.1073/pnas.0912730107. Epub 2009 Dec 4.
3
TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness.在常染色体隐性完全先天性静止性夜盲症患者中，瞬时受体电位阳离子通道亚家族M成员1（TRPM1）发生了突变。
Am J Hum Genet. 2009 Nov;85(5):720-9. doi: 10.1016/j.ajhg.2009.10.013. Epub 2009 Nov 5.
4
Mutations in TRPM1 are a common cause of complete congenital stationary night blindness.瞬时受体电位阳离子通道亚家族M成员1（TRPM1）的突变是完全性先天性静止性夜盲的常见病因。
Am J Hum Genet. 2009 Nov;85(5):730-6. doi: 10.1016/j.ajhg.2009.10.012. Epub 2009 Nov 5.
5
Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans.基因TRPM1的隐性突变会消除ON双极细胞的功能，并导致人类完全性先天性静止性夜盲。
Am J Hum Genet. 2009 Nov;85(5):711-9. doi: 10.1016/j.ajhg.2009.10.003. Epub 2009 Oct 29.
6
TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells.TRPM1 在视网膜 ON-双极细胞的去极化光反应中是必需的。
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19174-8. doi: 10.1073/pnas.0908711106. Epub 2009 Oct 27.
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A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.一种类瞬时受体电位通道介导视杆双极细胞中的突触传递。
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TRPM1 forms ion channels associated with melanin content in melanocytes.瞬时受体电位阳离子通道蛋白1（TRPM1）形成与黑素细胞中黑色素含量相关的离子通道。
Sci Signal. 2009 May 12;2(70):ra21. doi: 10.1126/scisignal.2000146.
9
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells.瞬时受体电位M3通道是胰腺β细胞中的离子otropic类固醇受体。 （注：原文中“ionotropic”可能有误，推测可能是“ionotropic”，意为“亲离子的” ，准确翻译应该是：瞬时受体电位M3通道是胰腺β细胞中的亲离子类固醇受体。 ）
Nat Cell Biol. 2008 Dec;10(12):1421-30. doi: 10.1038/ncb1801. Epub 2008 Nov 2.
10
Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus).瞬时受体电位阳离子通道蛋白1（TRPM1）的差异基因表达，这是阿帕卢萨马（马属动物）先天性静止性夜盲和皮毛斑点图案（LP）的潜在成因。
Genetics. 2008 Aug;179(4):1861-70. doi: 10.1534/genetics.108.088807. Epub 2008 Jul 27.
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