Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Environ Mol Mutagen. 2010 Jun;51(5):427-39. doi: 10.1002/em.20582.
Exciting new studies are increasingly strengthening the link between mitochondrial mutagenesis and tumor progression. Here we provide a comprehensive review and meta-analysis of studies reporting on mitochondrial DNA mutations in common human cancers. We discuss possible mechanisms by which mitochondrial DNA mutations may influence carcinogenesis, outline important caveats for interpreting the detected mutations--particularly differentiating causality from association--and suggest how new mutational assays may help resolve fundamental controversies in the field and delineate the origin and expansion of neoplastic cell lineages. Finally, we discuss the potential clinical utility of mtDNA mutations for improving the sensitivity of early cancer diagnosis, rapidly detecting cancer recurrence, and predicting the disease outcome.
激动人心的新研究越来越多地加强了线粒体突变与肿瘤进展之间的联系。在这里，我们对报告常见人类癌症中线粒体 DNA 突变的研究进行了全面的综述和荟萃分析。我们讨论了线粒体 DNA 突变可能影响致癌作用的可能机制，概述了解释检测到的突变时需要注意的重要问题——特别是要区分因果关系和相关性——并提出了新的突变检测方法如何帮助解决该领域的基本争议，并阐明肿瘤细胞谱系的起源和扩展。最后，我们讨论了 mtDNA 突变在提高早期癌症诊断的敏感性、快速检测癌症复发和预测疾病结局方面的潜在临床应用。
