Gabrilevskaia O V, Gladkikh O P, Ivanov A A, Leskov V P, Nikiforova N V, Shilov E M, Tareeva I E, Pal'tsev M A, Kirpatovskiĭ V I
Biull Eksp Biol Med. 1991 Mar;111(3):229-32.
We investigated the intensiveness of the cell proliferation, number of mononuclear leucocytes (MNL) and production of interleukin-1 (IL-1) in glomerular cell cultures of rats with nephrotoxic serum (NTS) nephritis and control (C) rats. Five days after intravenous injection of nephrotoxic serum from rabbits the glomeruli were isolated, treated with collagenase and cultured over a period of 20 days. In cultures the number and intensity of mesangial cell proliferation in the NTS group were significantly higher than in the C group. Thus, the intensive mesangial cell proliferation in experimental nephrotoxic serum nephritis is related to infiltration of glomerulus by MNL of bone marrow origin with increased production of IL-1.
我们研究了肾毒性血清（NTS）肾炎大鼠和对照（C）大鼠肾小球细胞培养物中细胞增殖的强度、单核白细胞（MNL）数量以及白细胞介素-1（IL-1）的产生。在静脉注射兔肾毒性血清5天后，分离肾小球，用胶原酶处理，并培养20天。在培养物中，NTS组系膜细胞增殖的数量和强度显著高于C组。因此，实验性肾毒性血清肾炎中强烈的系膜细胞增殖与骨髓来源的MNL浸润肾小球及IL-1产生增加有关。
