• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease.

作者信息

Ferreon Allan Chris M, Moran Crystal R, Ferreon Josephine C, Deniz Ashok A

机构信息

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines MB-19, La Jolla, CA 92037, USA.

出版信息

Angew Chem Int Ed Engl. 2010 May 3;49(20):3469-72. doi: 10.1002/anie.201000378.

DOI:10.1002/anie.201000378
PMID:20544898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2972640/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8108/2972640/eba028d55e8b/anie0049-3469-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8108/2972640/450488a0a797/anie0049-3469-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8108/2972640/eba028d55e8b/anie0049-3469-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8108/2972640/450488a0a797/anie0049-3469-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8108/2972640/eba028d55e8b/anie0049-3469-f2.jpg

相似文献

1
Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease.与帕金森病相关的突变对α-突触核蛋白折叠态势的改变。
Angew Chem Int Ed Engl. 2010 May 3;49(20):3469-72. doi: 10.1002/anie.201000378.
2
Effect of reparation of repeat sequences in the human alpha-synuclein on fibrillation ability.人类α-突触核蛋白中重复序列修复对纤维化能力的影响。
Int J Biol Sci. 2006 Oct 2;3(1):1-7. doi: 10.7150/ijbs.3.1.
3
Parkinson's disease as a member of Prion-like disorders.帕金森病作为朊病毒样疾病的一员。
Virus Res. 2015 Sep 2;207:38-46. doi: 10.1016/j.virusres.2014.10.016. Epub 2014 Nov 4.
4
The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates α-synuclein aggregation and membrane binding.新发现的帕金森病相关芬兰突变(A53E)可减弱α-突触核蛋白的聚集和膜结合。
Biochemistry. 2014 Oct 21;53(41):6419-21. doi: 10.1021/bi5010365. Epub 2014 Oct 10.
5
Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.甲基苯丙胺与α-突触核蛋白结合,并导致构象变化,这种变化可以通过纳米孔分析检测到。
FEBS Lett. 2012 Sep 21;586(19):3222-8. doi: 10.1016/j.febslet.2012.06.040. Epub 2012 Jul 4.
6
Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease.控制导致帕金森病的α-突触核蛋白A53T突变体的聚集倾向。
Biochem Biophys Res Commun. 2009 Sep 18;387(2):305-9. doi: 10.1016/j.bbrc.2009.07.008. Epub 2009 Jul 4.
7
The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro.帕金森病相关的 H50Q 突变加速了α-突触核蛋白的体外聚集。
Biochemistry. 2013 Oct 8;52(40):6925-7. doi: 10.1021/bi400999d. Epub 2013 Sep 23.
8
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.小分子介导的囊泡相关螺旋α-突触核蛋白稳定化抑制致病错误折叠和聚集。
Nat Commun. 2014 Dec 19;5:5857. doi: 10.1038/ncomms6857.
9
Molecular mechanisms of alpha-synuclein neurodegeneration.α-突触核蛋白神经变性的分子机制
Biochim Biophys Acta. 2009 Jul;1792(7):616-24. doi: 10.1016/j.bbadis.2008.09.013. Epub 2008 Oct 9.
10
Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties.酪氨酸突变为丙氨酸对α-突触核蛋白纤维化及结构特性的影响。
Biochim Biophys Acta. 2008 Oct;1782(10):581-5. doi: 10.1016/j.bbadis.2008.07.004. Epub 2008 Jul 22.

引用本文的文献

1
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases.液-液相分离在病理性蛋白质积累中的作用:神经退行性疾病机制的新视角
Aging Dis. 2024 Apr 20;16(2):769-786. doi: 10.14336/AD.2024.0209.
2
single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates of monomeric α-synuclein.关于生化扰动对单体α-突触核蛋白构象中间体影响的单分子研究
APL Bioeng. 2024 Mar 1;8(1):016114. doi: 10.1063/5.0188714. eCollection 2024 Mar.
3
Aggregation of Disordered Proteins Associated with Neurodegeneration.

本文引用的文献

1
Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.通过单分子荧光探测α-突触核蛋白结合与构象转换的相互作用
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5645-50. doi: 10.1073/pnas.0809232106. Epub 2009 Mar 17.
2
Alpha-synuclein binds large unilamellar vesicles as an extended helix.α-突触核蛋白以伸展的螺旋形式结合大单层囊泡。
Biochemistry. 2009 Mar 24;48(11):2304-6. doi: 10.1021/bi900114z.
3
Linking folding and binding.连接折叠与结合
与神经退行性疾病相关的无序蛋白质聚集。
Int J Mol Sci. 2023 Feb 8;24(4):3380. doi: 10.3390/ijms24043380.
4
Quantitative interrogation of protein co-aggregation using multi-color fluorogenic protein aggregation sensors.使用多色荧光蛋白聚集传感器对蛋白质共聚集进行定量分析。
Chem Sci. 2021 May 20;12(24):8468-8476. doi: 10.1039/d1sc01122g.
5
The structural heterogeneity of α-synuclein is governed by several distinct subpopulations with interconversion times slower than milliseconds.α-突触核蛋白的结构异质性受几个不同亚群控制,这些亚群之间的转化时间慢于毫秒。
Structure. 2021 Sep 2;29(9):1048-1064.e6. doi: 10.1016/j.str.2021.05.002. Epub 2021 May 19.
6
Untangling the Conformational Polymorphism of Disordered Proteins Associated With Neurodegeneration at the Single-Molecule Level.在单分子水平上解析与神经退行性疾病相关的无序蛋白质的构象多态性
Front Mol Neurosci. 2020 Jan 10;12:309. doi: 10.3389/fnmol.2019.00309. eCollection 2019.
7
Probing the Basis of α-Synuclein Aggregation by Comparing Simulations to Single-Molecule Experiments.通过将模拟与单分子实验进行比较来探究α-突触核蛋白聚集的基础。
Biophys J. 2019 Sep 17;117(6):1125-1135. doi: 10.1016/j.bpj.2019.08.013. Epub 2019 Aug 16.
8
Direct Single-Molecule Observation of Sequential DNA Bending Transitions by the Sox2 HMG Box.Sox2 HMG 盒对 DNA 弯曲转变的序列进行直接单分子观察。
Int J Mol Sci. 2018 Dec 4;19(12):3865. doi: 10.3390/ijms19123865.
9
Acetylation Disfavors Tau Phase Separation.乙酰化不利于 Tau 相分离。
Int J Mol Sci. 2018 May 4;19(5):1360. doi: 10.3390/ijms19051360.
10
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.用分子模拟深入了解阿尔茨海默病和帕金森病的分子机制:了解与病理学相关的无序蛋白质中人工和病理性错义突变的作用。
Int J Mol Sci. 2018 Jan 24;19(2):336. doi: 10.3390/ijms19020336.
Curr Opin Struct Biol. 2009 Feb;19(1):31-8. doi: 10.1016/j.sbi.2008.12.003. Epub 2009 Jan 20.
4
Single-molecule FRET reveals structural heterogeneity of SDS-bound alpha-synuclein.单分子荧光共振能量转移揭示了与十二烷基硫酸钠结合的α-突触核蛋白的结构异质性。
Chembiochem. 2009 Feb 13;10(3):436-9. doi: 10.1002/cbic.200800644.
5
Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers.致病性突变使α-突触核蛋白单分子的平衡向结构化构象转变。
Chembiochem. 2009 Jan 5;10(1):176-83. doi: 10.1002/cbic.200800581.
6
Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement.通过定点自旋标记和计算优化得到的膜结合α-突触核蛋白的结构
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19666-71. doi: 10.1073/pnas.0807826105. Epub 2008 Dec 9.
7
alpha-Synuclein misfolding: single molecule AFM force spectroscopy study.α-突触核蛋白错误折叠:单分子原子力显微镜力谱研究
J Mol Biol. 2008 Dec 26;384(4):992-1001. doi: 10.1016/j.jmb.2008.10.006. Epub 2008 Oct 11.
8
Navigating the folding energy landscape of green fluorescent protein.探索绿色荧光蛋白的折叠能量景观。
Angew Chem Int Ed Engl. 2008;47(43):8192-5. doi: 10.1002/anie.200802987.
9
Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles.膜结合的α-突触核蛋白形成一个延伸的螺旋结构:使用囊泡、双分子层和棒状胶束进行的长距离脉冲电子自旋共振测量。
J Am Chem Soc. 2008 Oct 1;130(39):12856-7. doi: 10.1021/ja804517m. Epub 2008 Sep 6.
10
Probing protein-chaperone interactions with single-molecule fluorescence spectroscopy.用单分子荧光光谱法探究蛋白质-伴侣蛋白的相互作用。
Angew Chem Int Ed Engl. 2008;47(33):6184-8. doi: 10.1002/anie.200800298.