帕金森病作为朊病毒样疾病的一员。
Parkinson's disease as a member of Prion-like disorders.
作者信息
Herva Maria Eugenia, Spillantini Maria Grazia
机构信息
The Clifford Allbutt Building, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
The Clifford Allbutt Building, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
出版信息
Virus Res. 2015 Sep 2;207:38-46. doi: 10.1016/j.virusres.2014.10.016. Epub 2014 Nov 4.
Parkinson's disease is one of several neurodegenerative diseases associated with a misfolded, aggregated and pathological protein. In Parkinson's disease this protein is alpha-synuclein and its neuronal deposits in the form of Lewy bodies are considered a hallmark of the disease. In this review we describe the clinical and experimental data that have led to think of alpha-synuclein as a prion-like protein and we summarize data from in vitro, cellular and animal models supporting this view.
帕金森病是几种与错误折叠、聚集和病理性蛋白质相关的神经退行性疾病之一。在帕金森病中，这种蛋白质是α-突触核蛋白，其以路易小体形式存在的神经元沉积物被认为是该疾病的一个标志。在这篇综述中，我们描述了促使人们将α-突触核蛋白视为一种朊病毒样蛋白的临床和实验数据，并总结了支持这一观点的体外、细胞和动物模型的数据。
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