慢性炎症性脱髓鞘性多发性神经病中的不宁腿综合征。

Restless legs syndrome in chronic inflammatory demyelinating polyneuropathy.

机构信息

Department of Neurology, Neuromuscular Clinic, University Hospitals of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.

出版信息

Muscle Nerve. 2010 Aug;42(2):252-6. doi: 10.1002/mus.21684.

DOI:10.1002/mus.21684

PMID:20544936

Abstract

The prevalence of restless legs syndrome (RLS) is unknown in chronic inflammatory demyelinating polyneuropathy (CIDP). We prospectively studied 28 patients with CIDP. Prevalence of RLS in CIDP was ascertained by face-to-face interview using validated criteria and compared with that in 28 age- and gender-matched controls. Eleven (39.3%) CIDP patients were diagnosed with RLS, compared with 2 (7.1%) controls (P < 0.01). A significant correlation was ascertained between presence of RLS and lower limb weakness, functional disability, and summated compound muscle action potential (CMAP). The prevalence of RLS in CIDP was significantly higher than in controls in our study population, approaching 40%. Screening for RLS in CIDP patients may be appropriate, particularly in those with weakness, disability, and motor axonal loss in the lower limbs. Our findings may otherwise suggest the existence of peripheral components to the pathophysiology of RLS in patients with CIDP.

摘要

不宁腿综合征（RLS）在慢性炎症性脱髓鞘性多发性神经病（CIDP）中的患病率尚不清楚。我们前瞻性研究了 28 例 CIDP 患者。通过使用经过验证的标准进行面对面访谈来确定 CIDP 中 RLS 的患病率，并与 28 名年龄和性别匹配的对照进行比较。在 11 例（39.3%）CIDP 患者中诊断为 RLS，而在 2 例（7.1%）对照组中诊断为 RLS（P < 0.01）。确定 RLS 的存在与下肢无力、功能障碍和总和复合肌肉动作电位（CMAP）之间存在显著相关性。在我们的研究人群中，CIDP 患者中 RLS 的患病率明显高于对照组，接近 40%。在 CIDP 患者中筛查 RLS 可能是合适的，特别是在那些下肢有无力、残疾和运动轴突丧失的患者中。我们的发现可能表明 CIDP 患者 RLS 的病理生理学存在外周成分。