Lu Ying, Chen Zhi-mei, Xu Wei-lai, Mu Qi-tian, Jin Jie
Department of Hematology, Ningbo First Hospital, Ningbo 315000, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 May;39(3):241-5. doi: 10.3785/j.issn.1008-9292.2010.03.005.
To investigate the clinical characteristics of acute myeloid leukemia patients with 3q abnormalities.
Conventional cytogenetic analysis of R-banding was used to detect the abnormalities of 3q in 657 patients with acute myeloid leukemia (AML).
Twenty-four (3.7%) out of 657 patients had abnormalities of 3q, of which 3q21 or 3q26 were involved in 18 cases (75.0%); 3q21q26 abnormalities were harbored in 11 patients (45.8%), including 9 of t (3;3) and 2 cases of inv (3), of which 3 cases progressed from MDS. Ten patients presented with normal or elevated platelets and their bone marrow morphologies showed abnormal and striking proliferation of megakaryocytes. While in other 7 patients with 3q21 or 3q26, no one presented with high platelets and megakaryocytes. All 24 patients with 3q abnormalities received chemotherapies and only 4 patients achieved short-term remission with a median survival time of 6.7 months.
3q21q26 anomaly is the most common karyotype in acute myeloid patients with 3q abnormalities. The patients with 3q anomaly had extremely poorer treatment outcome and prognosis.
探讨急性髓系白血病伴3q异常患者的临床特征。
采用常规R显带细胞遗传学分析检测657例急性髓系白血病（AML）患者的3q异常情况。
657例患者中有24例（3.7%）存在3q异常，其中18例（75.0%）涉及3q21或3q26；11例（45.8%）存在3q21q26异常，包括9例t(3;3)和2例inv(3)，其中3例由骨髓增生异常综合征进展而来。10例患者血小板正常或升高，其骨髓形态显示巨核细胞异常且显著增殖。而其他7例3q21或3q26异常患者中，无一人血小板及巨核细胞升高。所有24例3q异常患者均接受了化疗，仅4例获得短期缓解，中位生存时间为6.7个月。
3q21q26异常是急性髓系白血病伴3q异常患者最常见的核型。3q异常患者的治疗效果及预后极差。
