Li Yinqing, Zhao Yu, Sun Xiaodi, Qu Xiaobo
Changchun University of Traditional Chinese Medicine, Changchun 130117, China.
Zhongguo Zhong Yao Za Zhi. 2010 Mar;35(6):759-62. doi: 10.4268/cjcmm20100622.
The objective was to evaluate the preventive and therapeutic effects of the collagen hydrolysate extracted from Sika deer velvet (CSDV) on osteoporosis rats induced by retinoicacid. Histomorphometric indices and serum biochemical parameters were measured in osteoporosis rats treated with/without antler collagen and in sham-operated rats. Our results were as follows: compared with the osteoporosis group, significant elevation in the levels of bone mineral density (BMD), Ca, P and static histomorphometric indexes and biomechanical properties, but reduction in the level of serum alkaline phosphatase (ALP) were observed in antler collagen-treated groups. However, the above function with the collagenase solution velvet material varied with the different doses. In conclusion, the extracted collagen is found to play a role in the prevention and treatment of osteoporosis rats by retinoic acid.
目的是评估从梅花鹿鹿茸中提取的胶原蛋白水解物（CSDV）对维甲酸诱导的骨质疏松大鼠的预防和治疗作用。在接受/未接受鹿茸胶原蛋白治疗的骨质疏松大鼠以及假手术大鼠中测量了组织形态计量学指标和血清生化参数。我们的结果如下：与骨质疏松组相比，鹿茸胶原蛋白治疗组的骨矿物质密度（BMD）、钙、磷水平以及静态组织形态计量学指标和生物力学性能显著升高，但血清碱性磷酸酶（ALP）水平降低。然而，胶原蛋白酶溶液处理的鹿茸材料的上述功能因剂量不同而有所变化。总之，发现提取的胶原蛋白在维甲酸诱导的骨质疏松大鼠的预防和治疗中发挥作用。
