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History of eczema herpeticum is associated with the inability to induce human β-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis.

作者信息

Hata T R, Kotol P, Boguniewicz M, Taylor P, Paik A, Jackson M, Nguyen M, Kabigting F, Miller J, Gerber M, Zaccaro D, Armstrong B, Dorschner R, Leung D Y M, Gallo R L

出版信息

Br J Dermatol. 2010 Sep;163(3):659-61. doi: 10.1111/j.1365-2133.2010.09892.x. Epub 2010 Jun 9.

DOI:10.1111/j.1365-2133.2010.09892.x
PMID:20545685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2966528/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f2/2966528/b01cd204c33a/nihms-216196-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f2/2966528/308fd579bc51/nihms-216196-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f2/2966528/b01cd204c33a/nihms-216196-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f2/2966528/308fd579bc51/nihms-216196-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f2/2966528/b01cd204c33a/nihms-216196-f0002.jpg

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History of eczema herpeticum is associated with the inability to induce human β-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis.疱疹样湿疹病史与特应性皮炎患者皮肤中无法诱导人β-防御素（HBD）-2、HBD-3和杀菌肽有关。
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Antimicrobial Peptide Loss, Except for LL-37, is not Characteristic of Atopic Dermatitis.除了 LL-37 之外，抗菌肽的缺失并不是特应性皮炎的特征。

本文引用的文献

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J Allergy Clin Immunol. 2009 Aug;124(2):260-9, 269.e1-7. doi: 10.1016/j.jaci.2009.05.020. Epub 2009 Jun 27.
2
IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.白细胞介素-4和白细胞介素-13通过信号转导和转录激活因子6（STAT-6）、细胞因子信号抑制因子（SOCS）-1和SOCS-3负向调节肿瘤坏死因子-α和干扰素-γ诱导的β-防御素表达。
J Immunol. 2007 Jul 15;179(2):984-92. doi: 10.4049/jimmunol.179.2.984.
3
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
Acta Derm Venereol. 2023 Jun 30;103:adv9413. doi: 10.2340/actadv.v103.9413.
4
Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis.微生物衍生的抗菌肽作为特应性皮炎的潜在治疗方法。
Front Immunol. 2023 Jan 25;14:1125635. doi: 10.3389/fimmu.2023.1125635. eCollection 2023.
5
Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis.特应性皮炎患儿的遗传/环境因素及免疫失调
J Asthma Allergy. 2022 Nov 23;15:1681-1700. doi: 10.2147/JAA.S293900. eCollection 2022.
6
The Genetics of Eczema Herpeticum.疱疹样湿疹的遗传学研究。
Clin Rev Allergy Immunol. 2022 Dec;63(3):390-397. doi: 10.1007/s12016-022-08953-x. Epub 2022 Sep 17.
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Potential Therapeutic Skin Microbiomes Suppressing -Derived Immune Responses and Upregulating Skin Barrier Function-Related Genes via the AhR Signaling Pathway.通过 AhR 信号通路，潜在治疗性皮肤微生物组抑制 - 衍生免疫反应并上调皮肤屏障功能相关基因。
Int J Mol Sci. 2022 Aug 23;23(17):9551. doi: 10.3390/ijms23179551.
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Skin Microbiota in Atopic Dermatitis.特应性皮炎的皮肤微生物组。
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