Cha Jimin, Kim Tae-Gyun, Ryu Ji-Hwan
Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea.
Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Exp Mol Med. 2025 Apr;57(4):703-713. doi: 10.1038/s12276-025-01427-y. Epub 2025 Apr 1.
Host life is inextricably linked to commensal microbiota, which play a crucial role in maintaining homeostasis and immune activation. A diverse array of commensal microbiota on the skin interacts with the host, influencing the skin physiology in various ways. Early-life exposure to commensal microbiota has long-lasting effects, and disruption of the epidermal barrier or transient exposure to these microorganisms can lead to skin dysbiosis and inflammation. Several commensal skin microbiota have the potential to function as either commensals or pathogens, both influencing and being influenced by the pathogenesis of skin inflammatory diseases. Here we explore the impact of various commensal skin microbiota on the host and elucidate the interactions between skin microbiota and host systems. A deeper understanding of these interactions may open new avenues for developing effective strategies to address skin diseases.
宿主的生命与共生微生物群紧密相连，共生微生物群在维持体内平衡和免疫激活方面发挥着关键作用。皮肤表面多种多样的共生微生物群与宿主相互作用，以多种方式影响皮肤生理。生命早期接触共生微生物群会产生长期影响，表皮屏障的破坏或短暂接触这些微生物会导致皮肤生态失调和炎症。几种皮肤共生微生物有可能既作为共生菌又作为病原体发挥作用，它们既影响皮肤炎症性疾病的发病机制，又受其影响。在这里，我们探讨各种皮肤共生微生物群对宿主的影响，并阐明皮肤微生物群与宿主系统之间的相互作用。对这些相互作用的更深入理解可能为开发治疗皮肤疾病的有效策略开辟新途径。
