Section of Dermatology, Di.S.E.M., University of Genoa, Genoa, Italy.
Clin Exp Dermatol. 2011 Jan;36(1):49-51. doi: 10.1111/j.1365-2230.2010.03855.x.
Sporotrichoid leishmaniasis is a sporadic form of cutaneous leishmaniasis, a protozoal infection, reported particularly in the Middle East. Clinically it occurs as nontender, subcutaneous, slightly erythematous nodules, often associated with lymphangitis, usually on exposed areas of the skin. Sometimes it occurs after treatment with a single dose of antimonials, and in older lesions, the biopsy can be negative for amastigotes. We report a case of cutaneous sporotrichoid leishmaniasis unresponsive to intralesional pentavalent antimonial therapy, which completely resolved after treatment with oral itraconazole. To our knowledge, this is only the third such case reported. We discuss the causes of dissemination of the nodular lesions and the negative results for amastigotes on re-biopsed lesions.
皮肤利什曼原虫病是一种皮肤利什曼原虫感染的散发性疾病，主要发生在中东地区。临床上表现为无触痛、皮下、轻度红斑的结节，常伴有淋巴管炎，通常发生在皮肤暴露部位。有时它发生在单次使用锑剂治疗后，在旧病变中，活检可能无法检测到无鞭毛体。我们报告了一例皮肤孢子丝菌病，对病灶内五价锑治疗无反应，经口服伊曲康唑治疗后完全缓解。据我们所知，这是第三个这样的病例。我们讨论了结节性病变播散的原因以及重新活检病变中无鞭毛体的阴性结果。
