Department of Surgery, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan.
Dis Esophagus. 2010 Nov;23(8):641-5. doi: 10.1111/j.1442-2050.2010.01070.x.
The chemotherapy regimen currently used for treating esophageal and gastric carcinoma has been either epirubicin, cisplatin, and fluorouracil (5-FU) or docetaxel, cisplatin, and 5-FU. Here, we report the efficacy and toxicity of doxorubicin, cisplatin, and 5-FU for only esophageal squamous cell carcinoma (ESCC). Between January 2000 and October 2008, a total of 41 ESCC patients with a distant metastasis were enrolled. The most common sites of metastasis were liver (26, 63.4%), lung (9, 22.0%), and bone (8, 19.5%). Doxorubicin was administered on day 1 at 30 mg/m(2) , cisplatin on days 1-5 at 14 mg/m(2)/day, and 5-FU on days 1-5 at 700 mg/m(2)/day. The median number of cycles was 2.0 (range 1-8). The dose intensities of doxorubicin, cisplatin, and 5-FU were 92.9, 92.4, and 92.5%, respectively. The overall response rate was 43.9%; one showed complete response, 17 showed partial response, 13 showed a stable disease, and 10 showed progressive disease (PD). The median survival time was 306 days (95% CI = 74-935) and the 1-year survival rate was 37.6%. Grade 3 neutropenia was seen in seven patients and grade 4 in one patient. Grade 3 fatigue, anorexia, mucositis, and diarrhea were observed in three, two, two, and one patient, respectively. This regimen is effective as a first-line therapy for ESCC with distant metastasis.
目前用于治疗食管癌和胃癌的化疗方案是表柔比星、顺铂和氟尿嘧啶（5-FU）或多西紫杉醇、顺铂和 5-FU。在这里，我们报告多柔比星、顺铂和 5-FU 仅用于食管鳞状细胞癌（ESCC）的疗效和毒性。2000 年 1 月至 2008 年 10 月期间，共纳入 41 例有远处转移的 ESCC 患者。转移的最常见部位是肝脏（26 例，63.4%）、肺（9 例，22.0%）和骨（8 例，19.5%）。多柔比星于第 1 天给予，剂量为 30mg/m²，顺铂于第 1-5 天给予，剂量为 14mg/m²/天，5-FU 于第 1-5 天给予，剂量为 700mg/m²/天。中位周期数为 2.0（范围 1-8）。多柔比星、顺铂和 5-FU 的剂量强度分别为 92.9%、92.4%和 92.5%。总缓解率为 43.9%；1 例完全缓解，17 例部分缓解，13 例疾病稳定，10 例疾病进展。中位生存时间为 306 天（95%CI=74-935），1 年生存率为 37.6%。7 例患者出现 3 级中性粒细胞减少，1 例患者出现 4 级中性粒细胞减少。3 例、2 例、2 例和 1 例患者分别出现 3 级疲劳、厌食、黏膜炎和腹泻。该方案对于有远处转移的 ESCC 是一种有效的一线治疗方案。
