Zhan Wenhua, Li Hanrui, Guo Yingying, Du Getao, Wu Yayan, Zhang Dexin
Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, China.
Front Oncol. 2020 May 5;10:622. doi: 10.3389/fonc.2020.00622. eCollection 2020.
Combination chemotherapy is a routine treatment for esophageal cancer, but some shortcomings, such as drug toxicity and side effects, greatly limit the clinical application of combination therapy. To overcome these shortcomings, we have developed a mesoporous silica nanoparticle system that was used to load doxorubicin and β-elemene. β-elemene was encapsulated in the pore of mesoporous silica nanoparticle and doxorubicin was electrostatically adsorbed on the surface of mesoporous silica nanoparticle by hyaluronic acid to construct dual drugs synergistic nanoparticles (bMED NPs, ~77.15 nm). studies demonstrated that bMED NPs had a good treatment effect in esophageal cancer cell lines. fluorescence imaging results demonstrated that bMED NPs could accumulate in tumor sites and achieve long-term circulation and continuous drug release. In addition, bMED NPs exhibited significant antitumor effects in the esophageal cancer mouse model, which may provide a great platform for esophageal cancer chemotherapy.
联合化疗是食管癌的常规治疗方法，但药物毒性和副作用等一些缺点极大地限制了联合治疗的临床应用。为克服这些缺点，我们开发了一种介孔二氧化硅纳米颗粒系统，用于负载阿霉素和β-榄香烯。β-榄香烯被包裹在介孔二氧化硅纳米颗粒的孔中，阿霉素通过透明质酸静电吸附在介孔二氧化硅纳米颗粒表面，构建双药协同纳米颗粒（bMED NPs，约77.15纳米）。研究表明，bMED NPs在食管癌细胞系中具有良好的治疗效果。荧光成像结果表明，bMED NPs可在肿瘤部位蓄积，实现长期循环和持续药物释放。此外，bMED NPs在食管癌小鼠模型中表现出显著的抗肿瘤作用，这可能为食管癌化疗提供一个很好的平台。
