Department of Family and Preventive Medicine, University of California, San Diego, CA, USA.
J Thromb Haemost. 2010 Sep;8(9):1912-8. doi: 10.1111/j.1538-7836.2010.03941.x.
Obesity is a risk factor for venous disease. We tested the associations between adipokines and the presence and severity of venous disease.
Participants for this analysis were drawn from a cohort of 2408 employees and retirees of a university in San Diego who were examined for venous disease using duplex ultrasonography. From this cohort, a case-control study sample of all 352 subjects with venous disease and 352 age-, sex- and race-matched subjects without venous disease were included in this analysis. All subjects completed health history questionnaires, had a physical examination with anthropometric measurements and had venous blood analyzed for adipokines.
After adjustment for age, sex and race, those with venous disease had significantly higher levels of body mass index (BMI), leptin and interleukin-6. Levels of resistin and tumor necrosis factor-alpha were also higher but of borderline significance (0.05 < P < 0.10). Compared with the lowest tertile and with adjustment for age, sex, race and BMI, the 2nd and 3rd tertiles of resistin (odds ratios, 1.9 and 1.7, respectively), leptin (1.7 and 1.7) and tumor necrosis factor-alpha (1.4 and 1.7) were associated with increasing severity of venous disease. Conversely, a 5 kg m⁻² increment in BMI was associated with a higher odds ratio (1.5) for venous disease, which was independent of the adipokines included in this study.
Both obesity and adipokines are significantly associated with venous disease. These associations appear to be independent of each other, suggesting potentially different pathways to venous disease.
肥胖是静脉疾病的一个危险因素。我们测试了脂肪因子与静脉疾病的存在和严重程度之间的关系。
本分析的参与者来自圣地亚哥一所大学的 2408 名员工和退休人员队列，他们使用双功能超声检查静脉疾病。从该队列中，选择所有 352 例静脉疾病患者和 352 例年龄、性别和种族匹配无静脉疾病的患者作为病例对照研究样本进行分析。所有患者均完成健康史问卷，进行体格检查和人体测量，并对静脉血进行脂肪因子分析。
在调整年龄、性别和种族后，患有静脉疾病的患者 BMI、瘦素和白细胞介素-6 水平明显较高。抵抗素和肿瘤坏死因子-α的水平也较高，但具有边缘意义（0.05<P<0.10）。与最低三分位数相比，与调整年龄、性别、种族和 BMI 后，抵抗素的第 2 和第 3 三分位数（比值比分别为 1.9 和 1.7）、瘦素（1.7 和 1.7）和肿瘤坏死因子-α（1.4 和 1.7）与静脉疾病严重程度的增加相关。相反，BMI 增加 5kg/m²与静脉疾病的比值比（1.5）较高，这与本研究中包含的脂肪因子无关。
肥胖和脂肪因子均与静脉疾病显著相关。这些关联似乎彼此独立，表明可能存在不同的静脉疾病途径。
