Merchant K M, Miller M A, Ashleigh E A, Dorsa D M
Department of Pharmacology, University of Washington, Seattle.
Brain Res. 1991 Feb 1;540(1-2):311-4. doi: 10.1016/0006-8993(91)90526-2.
The effects of an acute low dose of haloperidol on neurotensin mRNA-containing cells in rat forebrain was studied using in situ hybridization histochemistry. Within 1 h of a single dose of haloperidol (0.5 mg/kg) a nearly 3-fold increase in the number of cells that express the neurotensin/neuromedin N-encoding mRNA was observed in the dorsolateral striatum. However, the number of hybridization-positive cells did not appear to be affected in the nucleus accumbens, or the septal nuclei following treatment with the neuroleptic.
