Neurodermatology and Competence Center Pruritus, Clinic and Polyclinic for Dermatology, University Hospital of Münster, Germany.
J Dtsch Dermatol Ges. 2010 Oct;8(10):797-804. doi: 10.1111/j.1610-0387.2010.07463.x. Epub 2010 Jun 8.
Aquagenic pruritus (AP) can be induced by systemic diseases. The distribution of underlying diseases in a representative patient collective has not been investigated. This retrospective study aimed to determine the frequency and pruritus-specific parameter of systemic diseases in a series of patients.
Data of 39 patients with AP (24 f, 15 m; mean age: f: 51.3 ± 20.1, m: 57.2 ± 15.0 years) were obtained and statistically evaluated as follows: demographic data, pruritus characteristics, underlying diseases, family history.
30.8 % of patients exhibited polycythemia vera or myelofibrosis (Group 1: G1), in 69.2 % (G2) no underlying disease was found. 25.6 % had lactose intolerance as possible contributing factor. Women were significantly more common in G2 (p < 0.01), with a lower mean age (p < 0.01) and longer duration of AP (18.9 years, p < 0.01).
AP occurs frequently with polycythemia vera. Other underlying diseases are rare; in over half of the patients no cause can be detected. In 25 % lactose intolerance is present which possibly acts as co-factor. Demographic parameters (age, gender) allow estimation of the possible underlying disease in AP. Pruritus characteristics are similar in all groups and not helpful in determining the origin of AP.
水源性瘙痒症（AP）可由系统性疾病引起。尚未对代表性患者群体中的潜在疾病分布进行调查。本回顾性研究旨在确定一系列患者中系统性疾病的频率和瘙痒特异性参数。
获得了 39 例 AP 患者（24 例女性，15 例男性；平均年龄：女性：51.3 ± 20.1 岁，男性：57.2 ± 15.0 岁）的数据，并进行了统计学评估：人口统计学数据、瘙痒特征、潜在疾病、家族史。
30.8%的患者患有真性红细胞增多症或骨髓纤维化（第 1 组：G1），69.2%（G2）未发现潜在疾病。25.6%有乳糖不耐受作为可能的致病因素。女性在 G2 中更为常见（p < 0.01），平均年龄较低（p < 0.01），AP 持续时间较长（18.9 年，p < 0.01）。
AP 常与真性红细胞增多症有关。其他潜在疾病罕见；超过一半的患者无法检测到病因。25%存在乳糖不耐受，可能作为共同致病因素。人口统计学参数（年龄、性别）可用于估计 AP 中可能存在的潜在疾病。所有组的瘙痒特征相似，对确定 AP 的来源没有帮助。
