Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chałubińskiego 1, 50-368 Wrocław, Poland.
Acta Derm Venereol. 2018 Feb 7;98(2):185-190. doi: 10.2340/00015555-2812.
Aquagenic pruritus (AP) has a significant influence on quality of life (QoL) in patients with polycythaemia vera. This study analysed the impact of AP on patient well-being in 102 patients with polycythaemia vera. Intensity of pruritus was evaluated using a visual analogue scale (VAS), verbal rating scale (VRS) and a 4-item Itch Questionnaire. Psychosocial aspects of AP were assessed with the Hospital Anxiety and Depression Scale (HADS), EQ-5D and itch-specific QoL questionnaire (ItchyQoL). AP of mean duration 6.6 ± 8.6 years and intensity 4.8 ± 1.9 points (VAS) was present in 42/102 individuals. The prevalence of depression and anxiety among patients with AP was 23.8% and 9.5%, respectively. Depression was more frequent in the AP group (vs. non-AP). Moreover, patients with AP had higher HADS-anxiety scoring than those without pruritus (p = 0.005). A negative correlation was found between duration of AP and EQ-5D-VAS. The ItchyQol score of 37.3 ± 12.3 points was influenced by the extent (p =0.01) and duration of episodes of AP (p = 0.02). In conclusion, AP places an additional burden on patients with polycy-thaemia vera, negatively influencing their QoL.
水源性瘙痒症 (AP) 显著影响真性红细胞增多症患者的生活质量 (QoL)。本研究分析了 102 例真性红细胞增多症患者 AP 对患者健康状况的影响。瘙痒强度采用视觉模拟评分法 (VAS)、言语评定量表 (VRS) 和 4 项瘙痒问卷进行评估。采用医院焦虑抑郁量表 (HADS)、EQ-5D 和瘙痒特异性生活质量问卷 (ItchyQoL) 评估 AP 的心理社会方面。AP 平均持续 6.6±8.6 年，强度 4.8±1.9 分 (VAS)，42/102 人存在 AP。有瘙痒的患者中抑郁和焦虑的患病率分别为 23.8%和 9.5%。AP 组的抑郁更为常见 (vs. 非 AP 组)。此外，有瘙痒的患者 HADS 焦虑评分高于无瘙痒的患者 (p=0.005)。AP 持续时间与 EQ-5D-VAS 呈负相关。ItchyQol 评分 37.3±12.3 分受 AP 发作程度 (p=0.01) 和持续时间 (p=0.02) 的影响。总之，AP 给真性红细胞增多症患者带来了额外的负担，对其生活质量产生负面影响。
