Division of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan.
J Gastroenterol Hepatol. 2010 May;25(5):964-9. doi: 10.1111/j.1440-1746.2009.06194.x.
The aim of the present study was to assess the changes of liver stiffness (LS) and its associated factors in patients with chronic hepatitis C virus infection (HCV) after interferon (IFN)-based therapy.
Patients with chronic HCV who had previously undergone at least 20 weeks of IFN-based therapy were enrolled. The patients' initial LS measurement was taken at the time of enrollment, and a second LS measurement was made after an interval of at least 38 weeks. LS measurement was carried out with FibroScan, and changes of LS and its associated factors were analyzed.
One hundred and forty-four patients, including 95 sustained virological response (SVR) patients and 49 non-sustained virological response (NSVR) patients, were enrolled. There was a significant decrease of LS among SVR patients (median, 0.6; P < 0.001). NSVR patients showed an increase of LS (median, 0.8; P = 0.557). For SVR patients, a high initial LS was the predictive factor of a rapid reduction of LS values. However, advanced fibrosis stage before therapy, higher body mass index (BMI) and longer time remission were predictive factors for slow reduction of LS values.
LS decreases in sustained responders following IFN-based therapy in patients with chronic HCV. Advanced fibrosis, higher BMI, longer time for remission and lower initial LS value are predictive factors for a slow improvement of LS in sustained responders.
本研究旨在评估慢性丙型肝炎病毒（HCV）感染患者接受基于干扰素（IFN）治疗后的肝硬度（LS）变化及其相关因素。
纳入既往接受至少 20 周 IFN 治疗的慢性 HCV 患者。患者在入组时进行初始 LS 测量，并在至少 38 周后进行第二次 LS 测量。LS 测量采用 FibroScan 进行，分析 LS 的变化及其相关因素。
共纳入 144 例患者，其中 95 例为持续病毒学应答（SVR）患者，49 例为非持续病毒学应答（NSVR）患者。SVR 患者的 LS 显著下降（中位数 0.6；P<0.001）。NSVR 患者的 LS 增加（中位数 0.8；P=0.557）。对于 SVR 患者，初始 LS 较高是 LS 值快速降低的预测因素。然而，治疗前的晚期纤维化阶段、较高的体重指数（BMI）和较长的缓解时间是 LS 值缓慢降低的预测因素。
慢性 HCV 患者接受 IFN 治疗后，SVR 患者的 LS 降低。晚期纤维化、较高的 BMI、较长的缓解时间和较低的初始 LS 值是 SVR 患者 LS 缓慢改善的预测因素。
