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脑内组织移植中脑血管对高碳酸血症的反应性。

Cerebrovascular responsiveness to hypercapnia in intracerebral tissue transplants.

作者信息

Sharkey J, McBean D E, Kelly P A

机构信息

Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland, U.K.

出版信息

Brain Res. 1991 Feb 22;542(1):147-50. doi: 10.1016/0006-8993(91)91009-p.

DOI:10.1016/0006-8993(91)91009-p
PMID:2054653
Abstract

Cerebral blood flow was measured using [14C]iodoantipyrine quantitative autoradiography in rats which had previously undergone unilateral ibotenate-induced nucleus basalis lesion followed by intracortical implantation of foetal basal forebrain cell suspensions. Transplants had no effect upon host cortical blood flow, although within the transplant itself, blood flow was significantly lower than the contralateral site. Both the transplant and host cortex exhibited a similar degree of hyperaemia in response to hypercapnia.

摘要

使用[14C]碘安替比林定量放射自显影术测量大鼠的脑血流量,这些大鼠先前接受了单侧鹅膏蕈氨酸诱导的基底核损伤,随后进行了胎儿基底前脑细胞悬液的皮质内植入。移植对宿主皮质血流量没有影响,尽管在移植本身内部,血流量明显低于对侧部位。移植组织和宿主皮质对高碳酸血症的反应均表现出相似程度的充血。

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