Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh (U.K.).
Restor Neurol Neurosci. 1991 Jan 1;3(1):35-40. doi: 10.3233/RNN-1991-3104.
Blood-brain barrier permeability was measured using [14C]-labelled a-aminoisobutyric acid (AIB) quantitative auto-radiography in rats which had previously received unilateral ibotenate-induced lesions of the nucleus basalis followed by intracortical implantation of foetal basal forebrain cell suspensions. The permeability characteristics of intracortical transplants were found to be dependent upon the site of implantation. Superficial transplants were invariably associated with AIB transfer constants (Ki) 3- to 4-fold higher than those in corresponding contralateral host cortex. In transplants sited deep in host neocortex, Ki values were not significantly different from those measured in surrounding host brain tissue.
血脑屏障通透性采用[14C]标记的α-氨基异丁酸（AIB）定量自动放射照相术在大鼠中进行测量，这些大鼠先前接受了单侧内侧隔核诱导的博来霉素损伤，随后进行了胎儿基底前脑细胞悬浮液的皮质内植入。发现皮质内移植的通透性特征取决于植入部位。浅层移植总是与 AIB 转移常数（Ki）高 3-4 倍相关，高于相应的对侧宿主皮质。在宿主新皮质深处的移植部位，Ki 值与周围宿主脑组织测量值无显著差异。
