苯丙酸衍生物来源于海芒果树皮。
Phenylpropionic acid derivates from the bark of Cerbera manghas.
机构信息
School of Pharmaceutical Sciences, Hainan Medical University, Haikou 57110, China.
出版信息
Fitoterapia. 2010 Oct;81(7):852-4. doi: 10.1016/j.fitote.2010.05.010. Epub 2010 May 28.
Two new phenylpropionic acid derivates, cerberic acids A (1) and B (2), were isolated from the bark of Cerbera manghas. Their structures were established on the basis of spectroscopic methods including IR, ESI-FT-ICR-MS, 1D and 2D NMR. Primary bioassays showed that compound 1 possessed weak cytotoxic activity against HepG2, MCF-7, and HeLa cell lines with IC(50) values of 44.7, 52.3, 48.7 μg/ml, respectively.
从 Cerbera manghas 的树皮中分离得到了两个新的苯丙酸衍生物，即 Cerberic 酸 A（1）和 B（2）。它们的结构是基于包括 IR、ESI-FT-ICR-MS、1D 和 2D NMR 在内的光谱方法确定的。初步生物测定表明，化合物 1 对 HepG2、MCF-7 和 HeLa 细胞系具有较弱的细胞毒性活性，其 IC50值分别为 44.7、52.3 和 48.7 μg/ml。
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