Qu Jing, Hu You-Cai, Yu Shi-Shan, Chen Xiao-Guang, Li Yan
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Planta Med. 2006 Apr;72(5):442-9. doi: 10.1055/s-2005-916264.
A phytochemical investigation of the bark of Erythrophleum fordii led to six new cassaine diterpenoid amides (2, 4-8), together with two known compounds of the same skeleton, nor-cassamide ( 1) and nor-erythrosuamide (3). The structures were mainly established on the basis of 1D, 2D NMR and HR-MS analysis. The compounds 1, 2, 4, 6-8 exhibited selective cytotoxic activities (IC50 values < 10 microM) against A2780, KB, Bel-7402, BGC-823, MCF-7, HCT-8, Hela, PC-3M, A549 and Ketr3 human cancer cell lines in the MTT test.
对牛耳枫树皮进行植物化学研究，得到了6个新的格木二萜酰胺（2、4 - 8），以及两个具有相同骨架的已知化合物，去甲格木酰胺（1）和去甲红苏木酰胺（3）。其结构主要通过一维、二维核磁共振和高分辨质谱分析确定。在MTT试验中，化合物1、2、4、6 - 8对A2780、KB、Bel - 7402、BGC - 823、MCF - 7、HCT - 8、Hela、PC - 3M、A549和Ketr3人癌细胞系表现出选择性细胞毒活性（IC50值<10 microM）。
