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本文引用的文献

1
Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.自闭症中催产素受体缺乏的基因组和表观遗传学证据。
BMC Med. 2009 Oct 22;7:62. doi: 10.1186/1741-7015-7-62.
2
Further genetic evidence implicates the vasopressin system in childhood-onset mood disorders.进一步的遗传证据表明，加压素系统与儿童期起病的心境障碍有关。
Eur J Neurosci. 2009 Oct;30(8):1615-9. doi: 10.1111/j.1460-9568.2009.06930.x. Epub 2009 Oct 12.
3
Oxytocin receptor polymorphisms and adult attachment style in patients with depression.抑郁患者的催产素受体多态性与成人依恋风格。
Psychoneuroendocrinology. 2009 Nov;34(10):1506-14. doi: 10.1016/j.psyneuen.2009.05.006. Epub 2009 Jun 9.
4
Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects.正常受试者的催产素受体基因（OXTR）与情感、孤独和智力的关联。
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):860-6. doi: 10.1016/j.pnpbp.2009.04.004. Epub 2009 Apr 17.
5
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.与观察到的养育行为相关的催产素受体（OXTR）基因和5-羟色胺转运体（5-HTT）基因。
Soc Cogn Affect Neurosci. 2008 Jun;3(2):128-34. doi: 10.1093/scan/nsn004. Epub 2008 Feb 11.
6
Evidence of dysregulated peripheral oxytocin release among depressed women.抑郁症女性外周催产素释放失调的证据。
Psychosom Med. 2008 Nov;70(9):967-75. doi: 10.1097/PSY.0b013e318188ade4.
7
Associations among central nervous system serotonergic function and neuroticism are moderated by gender.中枢神经系统血清素能功能与神经质之间的关联受性别影响。
Biol Psychol. 2008 May;78(2):200-3. doi: 10.1016/j.biopsycho.2008.03.002. Epub 2008 Mar 12.
8
Parity mediates the association between infant feeding method and maternal depressive symptoms in the postpartum.胎次介导了产后婴儿喂养方式与母亲抑郁症状之间的关联。
Arch Womens Ment Health. 2007;10(6):259-66. doi: 10.1007/s00737-007-0207-7. Epub 2007 Nov 26.
9
Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders.抗利尿激素V1b受体基因（AVPR1B）与儿童期起病的情绪障碍之间存在关联的证据。
Arch Gen Psychiatry. 2007 Oct;64(10):1189-95. doi: 10.1001/archpsyc.64.10.1189.
10
Oxytocin attenuates amygdala responses to emotional faces regardless of valence.催产素可减弱杏仁核对情绪面孔的反应，无论其效价如何。
Biol Psychiatry. 2007 Nov 15;62(10):1187-90. doi: 10.1016/j.biopsych.2007.03.025. Epub 2007 Jul 9.

催产素或催乳素基因变异与儿童期起病的心境障碍无关。

No association between oxytocin or prolactin gene variants and childhood-onset mood disorders.

机构信息

Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.

出版信息

Psychoneuroendocrinology. 2010 Oct;35(9):1422-8. doi: 10.1016/j.psyneuen.2010.04.008. Epub 2010 May 23.

DOI:10.1016/j.psyneuen.2010.04.008
PMID:20547007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2941560/
Abstract

BACKGROUND

Oxytocin (OXT) and prolactin (PRL) are neuropeptide hormones that interact with the serotonin system and are involved in the stress response and social affiliation. In human studies, serum OXT and PRL levels have been associated with depression and related phenotypes. Our purpose was to determine if single nucleotide polymorphisms (SNPs) at the loci for OXT, PRL and their receptors, OXTR and PRLR, were associated with childhood-onset mood disorders (COMD).

METHODS

Using 678 families in a family-based association design, we genotyped 16 SNPs at OXT, PRL, OXTR and PRLR to test for association with COMD.

RESULTS

No significant associations were found for SNPs in the OXTR, PRL, or PRLR genes. Two of three SNPs 3' of the OXT gene were associated with COMD (p≤0.02), significant after spectral decomposition, but were not significant after additionally correcting for the number of genes tested. Supplementary analyses of parent-of-origin and proband sex effects for OXT SNPs by Fisher's Exact test were not significant after Bonferroni correction.

CONCLUSIONS

We have examined 16 OXT and PRL system gene variants, with no evidence of statistically significant association after correction for multiple tests.

摘要

背景

催产素（OXT）和催乳素（PRL）是与血清素系统相互作用的神经肽激素，参与应激反应和社交联系。在人类研究中，血清 OXT 和 PRL 水平与抑郁和相关表型有关。我们的目的是确定 OXT、PRL 及其受体 OXTR 和 PRLR 基因座的单核苷酸多态性（SNP）是否与儿童期发病的心境障碍（COMD）有关。

方法

我们使用基于家系的关联设计中的 678 个家系，对 OXT、PRL、OXTR 和 PRLR 中的 16 个 SNP 进行基因分型，以检测其与 COMD 的关联。

结果

OXTR、PRL 或 PRLR 基因中的 SNP 与 COMD 无关。OXT 基因 3'端的三个 SNP 中的两个与 COMD 相关（p≤0.02），经光谱分解后具有统计学意义，但在额外校正所测试基因数量后则不显著。Fisher 精确检验对 OXT SNP 的亲源性和先证者性别效应的补充分析，在经过 Bonferroni 校正后没有统计学意义。

结论

我们已经检查了 16 个 OXT 和 PRL 系统基因变体，在进行多次检验校正后，没有证据表明存在统计学上显著的关联。