催产素或催乳素基因变异与儿童期起病的心境障碍无关。
No association between oxytocin or prolactin gene variants and childhood-onset mood disorders.
机构信息
Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
出版信息
Psychoneuroendocrinology. 2010 Oct;35(9):1422-8. doi: 10.1016/j.psyneuen.2010.04.008. Epub 2010 May 23.
BACKGROUND
Oxytocin (OXT) and prolactin (PRL) are neuropeptide hormones that interact with the serotonin system and are involved in the stress response and social affiliation. In human studies, serum OXT and PRL levels have been associated with depression and related phenotypes. Our purpose was to determine if single nucleotide polymorphisms (SNPs) at the loci for OXT, PRL and their receptors, OXTR and PRLR, were associated with childhood-onset mood disorders (COMD).
METHODS
Using 678 families in a family-based association design, we genotyped 16 SNPs at OXT, PRL, OXTR and PRLR to test for association with COMD.
RESULTS
No significant associations were found for SNPs in the OXTR, PRL, or PRLR genes. Two of three SNPs 3' of the OXT gene were associated with COMD (p≤0.02), significant after spectral decomposition, but were not significant after additionally correcting for the number of genes tested. Supplementary analyses of parent-of-origin and proband sex effects for OXT SNPs by Fisher's Exact test were not significant after Bonferroni correction.
CONCLUSIONS
We have examined 16 OXT and PRL system gene variants, with no evidence of statistically significant association after correction for multiple tests.
背景
催产素（OXT）和催乳素（PRL）是与血清素系统相互作用的神经肽激素，参与应激反应和社交联系。在人类研究中，血清 OXT 和 PRL 水平与抑郁和相关表型有关。我们的目的是确定 OXT、PRL 及其受体 OXTR 和 PRLR 基因座的单核苷酸多态性（SNP）是否与儿童期发病的心境障碍（COMD）有关。
方法
我们使用基于家系的关联设计中的 678 个家系，对 OXT、PRL、OXTR 和 PRLR 中的 16 个 SNP 进行基因分型，以检测其与 COMD 的关联。
结果
OXTR、PRL 或 PRLR 基因中的 SNP 与 COMD 无关。OXT 基因 3'端的三个 SNP 中的两个与 COMD 相关（p≤0.02），经光谱分解后具有统计学意义，但在额外校正所测试基因数量后则不显著。Fisher 精确检验对 OXT SNP 的亲源性和先证者性别效应的补充分析，在经过 Bonferroni 校正后没有统计学意义。
结论
我们已经检查了 16 个 OXT 和 PRL 系统基因变体，在进行多次检验校正后，没有证据表明存在统计学上显著的关联。
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