探寻自闭症患者胃肠道功能紊乱的遗传生物标志物。
Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism.
机构信息
Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, VIC, 3086, Australia.
La Trobe University, Level 4 Reid Building, 1 Kingsbury Drive, Bundoora, VIC, 3083, Australia.
出版信息
J Autism Dev Disord. 2020 Jan;50(1):76-86. doi: 10.1007/s10803-019-04231-6.
This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate statistical significance for the Prolactin (PRL) (OR 6.35, p value 0.069) and Interleukin 10 (IL-10) (OR 0.25, p value 0.087) SNPs. The GI dysfunction group had a strong statistical significance for the Cluster of Differentiation 38 (CD38) (OR 6.88, p value 0.005) and oxytocin receptor (OXTR) (OR 0.27, p value 0.036) SNPs. The potential use of PRL, IL-10, CD38, and OXTR SNP expression as biomarkers for GI dysfunction in autism warrants further research.
本研究旨在探讨胃肠道功能障碍症状的遗传生物标志物，以期为自闭症相关胃肠道功能障碍的遗传风险提供更多信息。对 60 名自闭症和/或胃肠道功能障碍患者的单核苷酸多态性进行了分析。自闭症组催乳素（PRL）（OR 6.35，p 值 0.069）和白细胞介素 10（IL-10）（OR 0.25，p 值 0.087）SNP 具有中度统计学意义。胃肠道功能障碍组分化群 38（CD38）（OR 6.88，p 值 0.005）和催产素受体（OXTR）（OR 0.27，p 值 0.036）SNP 具有统计学意义。PRL、IL-10、CD38 和 OXTR SNP 表达作为自闭症胃肠道功能障碍的生物标志物具有潜在的应用价值，值得进一步研究。
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