CIBP - Centre for Parasite Immunology and Biology, INSA, Porto, Portugal.
Exp Parasitol. 2010 Dec;126(4):526-35. doi: 10.1016/j.exppara.2010.06.012. Epub 2010 Jun 12.
We have previously identified the expression of an estradiol (E2)-related molecule by Schistosoma haematobium total antigen (Sh). We now show that this molecule has an antagonistic effect of estradiol in vitro. Our results are consistent with the existence of an estrogenic molecule that antagonizes the activity of estradiol. We found evidence for this molecule as we identified and characterized by mass spectrometry new estrogenic molecules previously unknown, present in schistosome worm extracts and sera of Schistosoma-infected individuals. We also show that Sh is able to interact in vitro with estrogen receptor (ER), explaining how host endocrine system can favor the establishment of schistosomes. These findings highlight the exploitation of the host endocrine system by schistosomes and represent an additional regulatory component of schistosome development that defines a novel paradigm enabling host-parasite interactions. The identification of these molecules opens new ways for the development of alternative drugs to treat schistosomiasis.
我们之前已经确定了曼氏血吸虫总抗原（Sh）表达的一种雌二醇（E2）相关分子。我们现在表明，这种分子在体外具有雌二醇的拮抗作用。我们的结果与存在一种雌激素分子一致，该分子拮抗雌二醇的活性。我们在鉴定和表征曼氏血吸虫虫体提取物和感染个体血清中以前未知的新雌激素分子时发现了这种分子的证据。我们还表明，Sh 能够在体外与雌激素受体（ER）相互作用，这解释了宿主内分泌系统如何有利于曼氏血吸虫的建立。这些发现强调了曼氏血吸虫对宿主内分泌系统的利用，并代表了曼氏血吸虫发育的另一个调节成分，定义了一种新的范例，使宿主-寄生虫相互作用成为可能。这些分子的鉴定为开发治疗血吸虫病的替代药物开辟了新途径。
