Department of Neurosurgery, Wellington Hospital, Riddiford Street, Newtown, Wellington 6021, New Zealand.
J Clin Neurosci. 2010 Sep;17(9):1155-8. doi: 10.1016/j.jocn.2010.02.006. Epub 2010 Jun 14.
Meningiomas are benign intracranial tumours treated by neurosurgical resection. Residual or recurrent tumour may be treated with radiotherapy. Effective molecular therapy for residual and recurrent meningiomas is currently unavailable. We tested meningiomas for In-ErbB-1 and ErbB-2, and the levels were compared to normal brain, peripheral nerve, glioblastoma multiforme and vestibular schwannoma. Our findings with immunohistochemistry and western blot analysis indicate a level of ErbB-1 similar to normal peripheral nerve, but a high expression of ErbB-2 similar to the vestibular schwannoma and glioblastoma multiforme. These preliminary results implicate a potential role for ErbB-2 in the benign tumourigenesis of meningioma consistent with the theoretical hierarchical interactions of homodimers of ErbB-2 that may be associated with low signal transduction.
脑膜瘤是通过神经外科切除治疗的良性颅内肿瘤。残留或复发的肿瘤可以用放疗治疗。目前尚无有效的针对残留和复发性脑膜瘤的分子治疗方法。我们检测了脑膜瘤中的 In-ErbB-1 和 ErbB-2，并将其水平与正常大脑、周围神经、多形性胶质母细胞瘤和前庭神经鞘瘤进行了比较。我们的免疫组织化学和 Western blot 分析结果表明，ErbB-1 的水平与正常周围神经相似，但 ErbB-2 的表达水平与前庭神经鞘瘤和多形性胶质母细胞瘤相似。这些初步结果表明，ErbB-2 可能在脑膜瘤的良性肿瘤发生中发挥作用，这与 ErbB-2 同源二聚体的理论层次相互作用一致，这种相互作用可能与低信号转导有关。
