Laurendeau Ingrid, Ferrer Marcela, Garrido Delia, D'Haene Nicky, Ciavarelli Patricia, Basso Armando, Vidaud Michel, Bieche Ivan, Salmon Isabelle, Szijan Irene
UMR745, INSERM, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris-Descartes, Paris, France.
Cancer Invest. 2009 Jul;27(6):691-8. doi: 10.1080/07357900802709175.
ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied. Meningiomas represent 30% of primary cranial tumors, are mostly benign, and prevail in the second half of life. Tumor therapy requires information about molecular alterations, thus we studied expression of ErbB receptor and ligand genes by real-time RT-PCR in different meningioma grades. Receptors were overexpressed (ErbB1, ErbB2) or underexpressed (ErbB3, ErbB4). Ligands EGF, TGFA, AREG, DTR, BTD were underexpressed and the neuregulins were overexpressed or underexpressed. A strong ErbB1-ErbB2 correlation was found. These data might be useful for gene therapy.
表皮生长因子受体（ErbB）家族受体介导肿瘤发生过程中主要的细胞功能，尽管它们在脑膜瘤中的作用尚未得到充分研究。脑膜瘤占原发性颅脑肿瘤的30%，大多为良性，且在生命的后半段较为常见。肿瘤治疗需要了解分子改变情况，因此我们通过实时逆转录聚合酶链反应（RT-PCR）研究了不同分级脑膜瘤中ErbB受体和配体基因的表达。受体出现过表达（ErbB1、ErbB2）或低表达（ErbB3、ErbB4）。配体表皮生长因子（EGF）、转化生长因子α（TGFA）、双调蛋白（AREG）、神经营养因子（DTR）、β-瘤调蛋白（BTD）低表达，而神经调节蛋白则出现过表达或低表达。发现ErbB1与ErbB2之间存在强相关性。这些数据可能对基因治疗有用。
