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QSART 中乙酰胆碱传递的凝胶与溶液载体的比较。

Comparison of a gel versus solution-based vehicle for the delivery of acetylcholine in QSART.

机构信息

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States.

出版信息

Auton Neurosci. 2010 Dec 8;158(1-2):123-6. doi: 10.1016/j.autneu.2010.05.005. Epub 2010 Jun 13.

Abstract

Quantitative Sudomotor Axon Reflex Testing is a useful measure of post ganglionic sudomotor function. The test is based on the iontophoresis of an acetylcholine solution which induces a local sweat response. We have previously described a gel-based vehicle that may provide another option for the iontophoresis of acetylcholine. It was our objective to compare the influence of the vehicle (gel versus solution) on sudomotor recordings and perceived discomfort. Results show gel-based vehicles are very similar to solution-based vehicles during Quantitative Sudomotor Axon Reflex Testing.

摘要

定量性汗反射测试是一种用于评估节后自主汗腺功能的有效方法。该测试基于电渗电泳将乙酰胆碱溶液导入皮肤,引起局部出汗反应。我们曾描述过一种基于凝胶的载体,它可能为乙酰胆碱的电渗电泳提供另一种选择。我们的目标是比较载体(凝胶与溶液)对汗反射记录和感知不适的影响。结果表明,在定量性汗反射测试中,基于凝胶的载体与基于溶液的载体非常相似。

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