生酮饮食治疗癫痫。
Ketogenic diet for treatment of epilepsy.
机构信息
BC Children's Hospital, Department of Pediatrics, Vancouver, BC V6H 3V4, Canada.
出版信息
Can Fam Physician. 2010 Jun;56(6):540-2.
Abstract
QUESTION
Families of children with epilepsy now ask about the ketogenic diet at clinic visits. Is it effective and safe to use for treatment of epilepsy?
ANSWER
The ketogenic diet can be considered an option for children with intractable epilepsy who use multiple antiepileptic drugs. It is a treatment of choice for seizures associated with glucose transporter protein deficiency syndrome (ie, De Vivo disease) and pyruvate dehydrogenase complex deficiency. The diet's strictness, unpalatability, and side effects limit its use, adversely affecting patients' compliance and clinical efficacy.
摘要
问题
患有癫痫的儿童的家属现在会在就诊时询问生酮饮食。生酮饮食作为治疗癫痫的方法，其效果和安全性如何？
答案
生酮饮食可被视为多种抗癫痫药物治疗无效的难治性癫痫儿童的一种选择。它是葡萄糖转运蛋白缺乏综合征（即 De Vivo 病）和丙酮酸脱氢酶复合体缺乏相关癫痫发作的首选治疗方法。该饮食的严格性、口感不佳和副作用限制了其使用，对患者的依从性和临床疗效产生不利影响。
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本文引用的文献
1
A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy.
Epilepsia. 2009 May;50(5):1109-17. doi: 10.1111/j.1528-1167.2008.01870.x. Epub 2008 Nov 19.
2
KetoCalculator: a web-based calculator for the ketogenic diet.
Epilepsia. 2008 Nov;49 Suppl 8:14-6. doi: 10.1111/j.1528-1167.2008.01824.x.
3
Ketogenic diet treatment in adults with refractory epilepsy: a prospective pilot study.
Seizure. 2009 Jan;18(1):30-3. doi: 10.1016/j.seizure.2008.06.001. Epub 2008 Aug 3.
4
The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial.
Lancet Neurol. 2008 Jun;7(6):500-6. doi: 10.1016/S1474-4422(08)70092-9. Epub 2008 May 2.
5
Efficacy and tolerability of the ketogenic diet according to lipid:nonlipid ratios--comparison of 3:1 with 4:1 diet.
Epilepsia. 2007 Apr;48(4):801-5. doi: 10.1111/j.1528-1167.2007.01025.x. Epub 2007 Mar 26.
6
Anticonvulsant mechanisms of the ketogenic diet.
Epilepsia. 2007 Jan;48(1):43-58. doi: 10.1111/j.1528-1167.2007.00915.x.
7
Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis.
J Child Neurol. 2006 Mar;21(3):193-8. doi: 10.2310/7010.2006.00044.
8
The ketogenic diet: from molecular mechanisms to clinical effects.
Epilepsy Res. 2006 Feb;68(2):145-80. doi: 10.1016/j.eplepsyres.2005.10.003.
9
Fasting versus gradual initiation of the ketogenic diet: a prospective, randomized clinical trial of efficacy.
Epilepsia. 2005 Nov;46(11):1810-9. doi: 10.1111/j.1528-1167.2005.00282.x.
10
Assessing the efficacy of antiepileptic treatments: the ketogenic diet.
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