Tillery Erika E, Ellis Katie D, Threatt Tiffaney B, Reyes Hannah A, Plummer Christopher S, Barney Logan R
Assistant Professor, Presbyterian College School of Pharmacy, Clinton, South Carolina.
Associate Professor, Presbyterian College School of Pharmacy, Clinton, South Carolina.
Ment Health Clin. 2021 May 12;11(3):211-219. doi: 10.9740/mhc.2021.05.211. eCollection 2021 May.
The ketogenic diet (KD) is a high-fat, low-carbohydrate, and moderate-protein diet that has shown benefit as a treatment in neurologic disorders and may serve as a therapeutic option in individuals with psychiatric disorders.
A search was conducted using EBSCOhost and PubMed databases for studies relating to ketogenic or low-carbohydrate diets and psychiatric disorders.
A total of 32 experimental or observational studies were identified by initial search strategies, 14 of which met the criteria to be included in this analysis. Although specific diet formulations varied somewhat between studies, they all generally examined low-carbohydrate dietary intake with the goal of producing a ketotic state. The studies included in this review indicated the KD was beneficial in reducing symptoms associated with various psychiatric disorders.
This review summarizes the available evidence regarding the efficacy of the ketogenic diet in psychiatric disease states. Data from the studies analyzed demonstrated a positive response in individuals who were able to remain on the diet, regardless of the disease state. However, there is a need for more data to clearly define the specific benefits the KD may provide.
生酮饮食（KD）是一种高脂肪、低碳水化合物和适量蛋白质的饮食，已显示出作为神经系统疾病治疗方法的益处，并且可能成为精神疾病患者的一种治疗选择。
使用EBSCOhost和PubMed数据库搜索与生酮或低碳水化合物饮食及精神疾病相关的研究。
通过初步搜索策略共识别出32项实验性或观察性研究，其中14项符合纳入本分析的标准。尽管不同研究之间的具体饮食配方略有差异，但它们总体上都研究了低碳水化合物饮食摄入，目的是产生酮症状态。本综述纳入的研究表明，生酮饮食有助于减轻与各种精神疾病相关的症状。
本综述总结了关于生酮饮食在精神疾病状态下疗效的现有证据。分析的研究数据表明，无论疾病状态如何，能够坚持该饮食的个体都有积极反应。然而，需要更多数据来明确生酮饮食可能提供的具体益处。
