Department of Oral Medicine, Periodontology and Diagnosis, Cairo University, Egypt.
Angiology. 2011 Jan;62(1):62-7. doi: 10.1177/0003319710371617. Epub 2010 Jun 13.
There is evidence supporting an association between cardiovascular disease (CVD) and periodontitis. We determined whether patients with chronic periodontitis, who are otherwise healthy individuals, have higher serum concentrations of emerging risk markers of CVD such as C-reactive protein (CRP) and interleukin 6 (IL-6) and investigated the effect of subsequent periodontal treatment on the levels of these markers. A total of 40 individuals were included in the study. Serum levels of CRP and IL-6 were estimated twice, once on the initial visits and the other 3 months after periodontal therapy. The mean CRP and IL-6 levels were significantly higher (P < .001) in the patients compared with controls and significantly decreased (P < .001) following periodontal treatment. This study suggests that periodontitis is a potential modifiable risk factor for CVD.
有证据表明心血管疾病 (CVD) 与牙周炎之间存在关联。我们确定了是否患有慢性牙周炎的患者,他们是健康个体,其血清中是否存在更高浓度的新兴 CVD 风险标志物,如 C 反应蛋白 (CRP) 和白细胞介素 6 (IL-6),并研究了随后的牙周治疗对这些标志物水平的影响。共有 40 人纳入研究。CRP 和 IL-6 的血清水平被估计了两次,一次是在初次就诊时,另一次是在牙周治疗 3 个月后。与对照组相比,患者的 CRP 和 IL-6 水平明显更高(P<0.001),且在牙周治疗后显著降低(P<0.001)。本研究表明牙周炎是 CVD 的一个潜在可改变的危险因素。