Loos B G, Craandijk J, Hoek F J, Wertheim-van Dillen P M, van der Velden U
Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), The Netherlands.
J Periodontol. 2000 Oct;71(10):1528-34. doi: 10.1902/jop.2000.71.10.1528.
Periodontitis is a common, often undiagnosed, chronic infection of the supporting tissues of the teeth, epidemiologically associated with cardiovascular diseases. Since C-reactive protein (CRP) and other systemic markers of inflammation have been identified as risk factors for cardiovascular diseases, we investigated whether these factors were elevated in periodontitis.
Consecutive adult patients with periodontitis (localized n = 53; generalized n = 54), and healthy controls (n = 43), all without any other medical disorder, were recruited and peripheral blood samples were taken.
Patients with generalized periodontitis and localized periodontitis had higher median CRP levels than controls (1.45 and 1.30 versus 0.90 mg/L, respectively, P = 0.030); 52% of generalized periodontitis patients and 36% of the localized periodontitis patients were sero-positive for interleukin-6 (IL-6), compared to 26% of controls (P= 0.008). Plasma IL-6 levels were higher in periodontitis patients than in controls (P = 0.015). Leukocytes were also elevated in generalized periodontitis (7.0 x 10(9)/L) compared to localized periodontitis and controls (6.0 and 5.8 x 10(9)/L, respectively, P= 0.002); this finding was primarily explained by higher numbers of neutrophils in periodontitis (P= 0.001). IL-6 and CRP correlated with each other, and both CRP and IL-6 levels correlated with neutrophils. The current findings for periodontitis were controlled for other known factors associated with cardiovascular diseases, including age, education, body mass index, smoking, hypertension, cholesterol, and sero-positivity for CMV, Chlamydia pneumoniae, and Helicobacter pylori.
Periodontitis results in higher systemic levels of CRP, IL-6, and neutrophils. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions, potentially increasing the risk for cardiac or cerebrovascular events.
牙周炎是一种常见的、常未被诊断出的牙齿支持组织慢性感染，在流行病学上与心血管疾病相关。由于C反应蛋白（CRP）和其他全身性炎症标志物已被确定为心血管疾病的危险因素，我们调查了这些因素在牙周炎中是否升高。
招募了连续的成年牙周炎患者（局限性牙周炎n = 53；广泛性牙周炎n = 54）和健康对照者（n = 43），所有患者均无任何其他疾病，并采集外周血样本。
广泛性牙周炎和局限性牙周炎患者的CRP中位数水平高于对照组（分别为1.45和1.30，而对照组为0.90mg/L，P = 0.030）；52%的广泛性牙周炎患者和36%的局限性牙周炎患者白细胞介素-6（IL-6）血清学呈阳性，而对照组为26%（P = 0.008）。牙周炎患者的血浆IL-6水平高于对照组（P = 0.015）。与局限性牙周炎和对照组相比，广泛性牙周炎患者的白细胞也升高（分别为7.0×10⁹/L、6.0和5.8×10⁹/L，P = 0.002）；这一发现主要是由于牙周炎患者中性粒细胞数量较多（P = 0.
