Higgins G, Abdulkareen A, Loutfi A, Gagnon J H, Shibata H R
Department of Surgery, McGill University, Montreal, Que.
Can J Surg. 1991 Jun;34(3):287-9.
The use of needle localization to aid excisional biopsy of nonpalpable breast lesions is now common, and the literature suggests that 13% to 33% of such lesions are malignant. During the 4 years from 1984 to 1988, all women who underwent fine-needle localization in preparation for biopsy were studied to identify factors that might facilitate the selection of those more likely to harbour a cancer, thus sparing patients with benign disease operative intervention. In all, 124 biopsies were performed on nonpalpable lesions that were suspicious on mammography; 51 lesions were malignant and 73 benign. The average age of the patients was 56 years (55 years for those with benign lesions and 61 for those with malignant lesions). The family history, history of breast disease, symptoms and calcification seen on mammography were not significantly different between the two groups. Only 25% of the malignant lesions were noninvasive. In 10% of the patients who had invasive lesions there was lymph-node involvement. The rate of malignancy in this patient population (41%) was slightly better than that reported in the literature, and a larger proportion of patients had noninvasive disease. The authors conclude that none of the above-mentioned risk factors could be used in the preoperative selection of patients for open biopsy.
使用针定位辅助不可触及乳腺病变的切除活检目前很常见，文献表明此类病变中有13%至33%为恶性。在1984年至1988年的4年期间，对所有接受细针定位以准备活检的女性进行了研究，以确定可能有助于选择更有可能患有癌症的患者的因素，从而避免对患有良性疾病的患者进行手术干预。总共对124例乳房X线摄影检查可疑的不可触及病变进行了活检；51例病变为恶性，73例为良性。患者的平均年龄为56岁（良性病变患者为55岁，恶性病变患者为61岁）。两组之间的家族史、乳腺疾病史、症状以及乳房X线摄影检查所见钙化情况无显著差异。仅25%的恶性病变为非浸润性。在患有浸润性病变的患者中，10%有淋巴结受累。该患者群体的恶性率（41%）略高于文献报道，且有更大比例的患者患有非浸润性疾病。作者得出结论，上述风险因素均不能用于术前选择进行开放活检的患者。
