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Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth.局部胰岛素样生长因子 I 的表达对出生时浦肯野神经元的存活至关重要。
Cell Death Differ. 2011 Jan;18(1):48-59. doi: 10.1038/cdd.2010.78. Epub 2010 Jul 2.
2
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.Neurog2是脊髓背侧Ptf1a-Rbpj转录复合体的直接下游靶点。
Development. 2009 Sep;136(17):2945-54. doi: 10.1242/dev.035352. Epub 2009 Jul 29.
3
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.锌指蛋白423（ZNF423）是维甲酸诱导分化所必需的关键因子，也是神经母细胞瘤预后的一个标志物。
Cancer Cell. 2009 Apr 7;15(4):328-40. doi: 10.1016/j.ccr.2009.02.023.
4
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition.神经祖细胞中的动态Notch信号传导与侧向抑制的修正观点。
Nat Neurosci. 2008 Nov;11(11):1247-51. doi: 10.1038/nn.2208.
5
Inhibition of myogenesis by Notch: evidence for multiple pathways.Notch对肌生成的抑制作用：多条途径的证据
J Cell Physiol. 2009 Jan;218(1):84-93. doi: 10.1002/jcp.21571.
6
Cerebellar development and disease.小脑的发育与疾病。
Curr Opin Neurobiol. 2008 Feb;18(1):12-9. doi: 10.1016/j.conb.2008.05.010. Epub 2008 May 29.
7
Purkinje cell subtype specification in the cerebellar cortex: early B-cell factor 2 acts to repress the zebrin II-positive Purkinje cell phenotype.小脑皮质中浦肯野细胞亚型的特异性：早期B细胞因子2可抑制zebrin II阳性浦肯野细胞表型。
Neuroscience. 2008 May 15;153(3):721-32. doi: 10.1016/j.neuroscience.2008.01.090. Epub 2008 Mar 6.
8
The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning.转录因子Zfp423/OAZ是小脑发育和中枢神经系统中线模式形成所必需的。
Dev Biol. 2007 Jul 1;307(1):43-52. doi: 10.1016/j.ydbio.2007.04.005. Epub 2007 Apr 12.
9
Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.锌指蛋白423/奥拉基酶在嗅觉神经发生过程中参与了发育转换。
Neuron. 2007 May 24;54(4):547-57. doi: 10.1016/j.neuron.2007.04.029.
10
The Hes gene family: repressors and oscillators that orchestrate embryogenesis.Hes基因家族：协调胚胎发育的抑制因子和振荡器。
Development. 2007 Apr;134(7):1243-51. doi: 10.1242/dev.000786. Epub 2007 Feb 28.

ZFP423 协调 Notch 和骨形态发生蛋白信号，选择性地上调 Hes5 基因的表达。

ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression.

机构信息

Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

出版信息

J Biol Chem. 2010 Oct 1;285(40):30814-24. doi: 10.1074/jbc.M110.142869. Epub 2010 Jun 14.

DOI:10.1074/jbc.M110.142869
PMID:20547764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2945575/
Abstract

Zinc finger protein 423 encodes a 30 Zn-finger transcription factor involved in cerebellar and olfactory development. ZFP423 is a known interactor of SMAD1-SMAD4 and of Collier/Olf-1/EBF proteins, and acts as a modifier of retinoic acid-induced differentiation. In the present article, we show that ZFP423 interacts with the Notch1 intracellular domain in mammalian cell lines and in Xenopus neurula embryos, to activate the expression of the Notch1 target Hes5/ESR1. This effect is antagonized by EBF transcription factors, both in cultured cells and in Xenopus embryos, and amplified in vitro by BMP4, suggesting that ZFP423 acts to integrate BMP and Notch signaling, selectively promoting their convergence onto the Hes5 gene promoter.

摘要

锌指蛋白 423 编码一个包含 30 个锌指的转录因子，参与小脑和嗅觉的发育。ZFP423 是 SMAD1-SMAD4 和 Collier/Olf-1/EBF 蛋白的已知相互作用蛋白，作为维甲酸诱导分化的调节剂。在本文中，我们表明 ZFP423 在哺乳动物细胞系和非洲爪蟾神经胚胚胎中与 Notch1 细胞内结构域相互作用，激活 Notch1 靶基因 Hes5/ESR1 的表达。这种效应在培养细胞和非洲爪蟾胚胎中被 EBF 转录因子拮抗，并在体外被 BMP4 放大，表明 ZFP423 作用于整合 BMP 和 Notch 信号，选择性地促进它们在 Hes5 基因启动子上的汇聚。