Peachey N S, Alexander K R, Fishman G A, Derlacki D J
Appl Opt. 1989 Mar 15;28(6):1145-50. doi: 10.1364/AO.28.001145.
Changes in the response characteristics of the flash electroretinogram (ERG) of the human cone system were studied during the time course of adaptation to a cone-isolating ganzfeld background. During light adaptation, the amplitudes of the b- and i-waves increased, while the implicit time of the b-wave decreased. The amplitude of the a-wave and the implicit times of the a- and i-waves did not change systematically during light adaptation. Luminance-response functions for b-wave amplitude were obtained at discrete times following background onset and were analyzed using the hyperbolic equation R/R(max) = L(n)/(L(n) + K(n)). The increase in b-wave amplitude was characterized by increases in R(max), K, and n. The decrease in b-wave implicit time was of a similar magnitude at all flash luminances. The amplitude increase of the i-wave only occurred at moderate flash luminances. The results provide a basis for optimizing the clinical recording of cone-isolated single-flash ERGs.
在适应锥细胞隔离的全视野背景的过程中，研究了人类锥细胞系统闪光视网膜电图（ERG）反应特性的变化。在明适应期间，b波和i波的振幅增加，而b波的隐含时间减少。在明适应期间，a波的振幅以及a波和i波的隐含时间没有系统性变化。在背景开始后的离散时间获得了b波振幅的亮度-反应函数，并使用双曲线方程R/R(max)=L(n)/(L(n)+K(n))进行分析。b波振幅的增加表现为R(max)、K和n的增加。在所有闪光亮度下，b波隐含时间的减少幅度相似。i波振幅的增加仅发生在中等闪光亮度下。这些结果为优化锥细胞隔离单闪光ERG的临床记录提供了依据。
