Hwang Seon-Wook, Hong Soon-Kwon, Kim Sang-Hyun, Seo Jong-Keun, Lee Deborah, Sung Ho-Suk
Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
Ann Dermatol. 2009 Feb;21(1):39-41. doi: 10.5021/ad.2009.21.1.39. Epub 2009 Feb 28.
Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in association with hydroxyurea treatment. A 75-year-old woman presented with leg ulcers, nail discoloration, and xerosis. The leg ulcers were refractory to conventional treatment. She had been taking oral hydroxyurea since being diagnosed with essential thrombocytosis in 2002. Hence, we suspected hydroxyurea-induced leg ulcers and discontinued her hydroxyurea treatment; the ulcers gradually healed thereafter. We present a rare case of hydroxyurea-induced leg ulcers in Korea.
羟基脲是一种细胞生长抑制剂，最近已成为治疗各种骨髓增殖性疾病的首选药物。羟基脲的皮肤副作用包括皮肤干燥、色素沉着、指甲变色和脱屑。与羟基脲治疗相关的腿部溃疡仅有罕见报道。一名75岁女性出现腿部溃疡、指甲变色和皮肤干燥。该腿部溃疡对常规治疗无效。自2002年被诊断为原发性血小板增多症以来，她一直在口服羟基脲。因此，我们怀疑是羟基脲引起的腿部溃疡，并停用了她的羟基脲治疗；此后溃疡逐渐愈合。我们报告了韩国一例罕见的羟基脲引起的腿部溃疡病例。
