Byun Ji Won, Hong Won Kyu, Song Hee Jin, Han Sung Hyub, Lee Hyeon Sook, Choi Gwang Seong, Shin Jeong Hyun
Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
Ann Dermatol. 2010 Feb;22(1):106-9. doi: 10.5021/ad.2010.22.1.106. Epub 2010 Feb 28.
Neutrophilic dermatosis of the dorsal hands (NDDH) is a localized, pustular variant of acute febrile neutrophilic dermatosis (Sweet syndrome). The lesions of NDDH clinically resemble those of Sweet syndrome (SS), but they differ from classic SS according to their locations (NDDH is predominantly restricted to the dorsal hands) and the smaller number of accompanying systemic symptoms. The histology of the NDDH lesion shows a dense dermal neutrophilic infiltration. The lesions rapidly resolve after systemic corticosteroid and/or dapsone therapy. We herein report on a case of neutrophilic dermatosis of the dorsal hands in a 34-year-old woman. The patient also had skin changes with erythematous plaque on the right lips.
手背嗜中性皮病（NDDH）是急性发热性嗜中性皮病（Sweet综合征）的一种局限性脓疱型。NDDH的皮损在临床上与Sweet综合征（SS）相似，但根据其部位（NDDH主要局限于手背）及伴随的全身症状较少，与经典的SS有所不同。NDDH皮损的组织学表现为真皮密集嗜中性粒细胞浸润。经全身用皮质类固醇和/或氨苯砜治疗后，皮损迅速消退。我们在此报告一例34岁女性的手背嗜中性皮病。该患者右侧唇部也有红斑性斑块的皮肤改变。
