Jeong Se Kyoo, Park Hyun Jung, Park Byeong Deog, Kim Il-Hwan
Research Division, NeoPharm Co., Ltd., Daejeon, Korea.
Ann Dermatol. 2010 May;22(2):143-8. doi: 10.5021/ad.2010.22.2.143. Epub 2010 May 17.
Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% to 80% of patients with end-stage renal disease (ESRD) complain about pruritus and xerosis, there are few reports on the effects of topical n-3 fatty acid on these symptoms.
In order to investigate the possible beneficial effects of topical n-3 fatty acid, oils extracted from chia (Salvia hispanica) seed were formulated into topical products, the effects of which were measured.
Five healthy volunteers having xerotic pruritus symptoms and 5 patients with pruritus caused by either ESRD or diabetes were involved in this study. A topical formulation containing 4% chia seed oils were applied for an 8-week duration. Subjective itching symptoms were assessed on a 6-point scale, as were other skin functions, namely transepidermal water loss and skin capacitance.
After the 8 weeks of application, significant improvements in skin hydration, lichen simplex chronicus, and prurigo nodularis were observed in all patients. A similar improvement was also observed among healthy volunteers with xerotic pruritus. Improvement of epidermal permeability barrier function and skin hydration, represented by trans-epidermal water loss and skin capacitance, respectively, were also observed. No adverse effects were observed in all the tested patients and volunteers.
Chia seed oil can be used as an adjuvant moisturizing agent for pruritic skin, including that of ESRD patients.
已经进行了多项研究来评估膳食n-3脂肪酸对肾功能不全患者的疗效。虽然约40%至80%的终末期肾病（ESRD）患者抱怨瘙痒和皮肤干燥，但关于局部应用n-3脂肪酸对这些症状影响的报道很少。
为了研究局部应用n-3脂肪酸可能产生的有益效果，将从奇亚籽（鼠尾草属）中提取的油制成局部用产品，并测定其效果。
5名有皮肤干燥瘙痒症状的健康志愿者和5名由ESRD或糖尿病引起瘙痒的患者参与了本研究。应用含4%奇亚籽油的局部用制剂，持续8周。主观瘙痒症状用6分制进行评估，其他皮肤功能，即经表皮水分流失和皮肤电容也进行评估。
应用8周后，所有患者的皮肤水合作用、慢性单纯性苔藓和结节性痒疹均有显著改善。有皮肤干燥瘙痒的健康志愿者也有类似改善。还观察到分别以经表皮水分流失和皮肤电容表示的表皮渗透屏障功能和皮肤水合作用的改善。所有受试患者和志愿者均未观察到不良反应。
奇亚籽油可作为瘙痒性皮肤（包括ESRD患者的皮肤）的辅助保湿剂。
