Kitada Masahiro, Ozawa Keisuke, Sato Kazuhiro, Matsuda Yoshinari, Hayashi Satoshi, Sasajima Tadahiro
First Department of Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Gen Thorac Cardiovasc Surg. 2010 Jun;58(6):298-301. doi: 10.1007/s11748-009-0523-0. Epub 2010 Jun 13.
Mediastinal teratomas are typically benign and asymptomatic, but they undergo sudden enlargement or rupture into neighboring organs in some patients owing to intratumoral hemorrhage, leading to serious complications. We report the case of a mediastinal mature teratoma that was discovered because of the sudden onset of chest pain accompanied by elevated preoperative serum CA19-9 levels. The patient was a 43-year-old man who experienced sudden chest pain and was brought to hospital in an ambulance. Chest radiography and computed tomography revealed a mediastinal tumor and a serum CA19-9 level that was elevated to 4377 U/ml. The tumor comprised soft tissue, fluid, and cystic components. The histological diagnosis was mature teratoma with peritumoral bleeding. Most epithelial components, including squamous epithelium and similar components in the bronchi, showed positive results for CA19-9 on immunohistological examination. The postoperative course was uneventful, and serum CA19-9 levels normalized.
纵隔畸胎瘤通常为良性且无症状，但在一些患者中，由于肿瘤内出血，它们会突然增大或破裂进入邻近器官，从而导致严重并发症。我们报告一例纵隔成熟畸胎瘤病例，该病例因突发胸痛伴术前血清CA19-9水平升高而被发现。患者为一名43岁男性，突发胸痛后由救护车送至医院。胸部X线摄影和计算机断层扫描显示纵隔肿瘤，血清CA19-9水平升高至4377 U/ml。肿瘤由软组织、液体和囊性成分组成。组织学诊断为成熟畸胎瘤伴肿瘤周围出血。大多数上皮成分，包括鳞状上皮和支气管中的类似成分，在免疫组织学检查中CA19-9呈阳性结果。术后病程平稳，血清CA19-9水平恢复正常。
