Section of Plant Physiology, Botanical Institute, University of Basel, Hebelstrasse 1, Basel, Switzerland.
Cell Mol Life Sci. 2010 Oct;67(20):3425-34. doi: 10.1007/s00018-010-0428-1. Epub 2010 Jun 13.
Plant pathogenic bacteria inject about 30 virulence effector proteins into the host cell using a specialized secretion apparatus. Bacteria which are unable to do this elicit host immunity and cannot grow inside living plant tissue. Thus, the primary function of the effectors is to suppress host immunity. The identity of individual effectors within each complement varies even between closely related bacterial strains, and effectors themselves act redundantly and are apparently interchangeable. Many effectors are known to target components of plant defense pathways, but it is difficult to study their role in molecular terms. For some of them, there is controversy about their mode of action. We propose that effectors act promiscuously by targeting host molecules with low specificity and affinity.
植物病原细菌使用一种专门的分泌装置将大约 30 种毒力效应蛋白注入宿主细胞。不能这样做的细菌会引起宿主免疫反应，并且不能在活体植物组织内生长。因此，效应子的主要功能是抑制宿主免疫。即使在密切相关的细菌菌株之间，每个补体中的个别效应子的身份也有所不同，并且效应子本身具有冗余性，显然可以互换。已知许多效应子针对植物防御途径的成分，但很难从分子角度研究它们的作用。对于其中一些，它们的作用模式存在争议。我们提出，效应子通过以低特异性和亲和力靶向宿主分子而表现出混杂性。
