文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wong-Dusting H K, La M, Rand M J

Department of Pharmacology, University of Melbourne, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Mar;18(3):131-6. doi: 10.1111/j.1440-1681.1991.tb01423.x.

In rabbit isolated perfused ear arteries denuded of endothelium, a low concentration of endothelin-1 (0.1 nmol/L) that had no direct vasoconstrictor action produced slowly developing enhancements of vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation. The enhancements reached maximal levels after 60 min of exposure to endothelin-1. 2. A higher concentration of endothelin-1 (1 nmol/L), which produced a slow-developing increase in perfusion pressure of 70 mmHg over the course of 1 h, significantly enhanced vasoconstrictor responses to sympathetic nerve stimulation for the first 30 min, after which there was no significant enhancement. Responses to noradrenaline were not enhanced by 1 nmol/L endothelin-1. 3. The enhancing effect of low concentrations of endothelin-1 on vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline may play a physiological role in modulating vasomotor function.

在兔离体灌流的去内皮耳动脉中，低浓度的内皮素-1（0.1纳摩尔/升）本身无直接血管收缩作用，但可使去甲肾上腺素和交感神经刺激引起的血管收缩反应缓慢增强。暴露于内皮素-1 60分钟后，增强作用达到最大水平。2. 较高浓度的内皮素-1（1纳摩尔/升）在1小时内使灌流压缓慢升高70毫米汞柱，在最初30分钟内可显著增强对交感神经刺激的血管收缩反应，此后则无显著增强。1纳摩尔/升的内皮素-1对去甲肾上腺素引起的反应无增强作用。3. 低浓度内皮素-1对交感神经刺激和去甲肾上腺素引起的血管收缩反应的增强作用，可能在调节血管运动功能中发挥生理作用。

Wong-Dusting H K, La M, Rand M J

Department of Pharmacology, University of Melbourne, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Mar;18(3):131-6. doi: 10.1111/j.1440-1681.1991.tb01423.x.

In rabbit isolated perfused ear arteries denuded of endothelium, a low concentration of endothelin-1 (0.1 nmol/L) that had no direct vasoconstrictor action produced slowly developing enhancements of vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation. The enhancements reached maximal levels after 60 min of exposure to endothelin-1. 2. A higher concentration of endothelin-1 (1 nmol/L), which produced a slow-developing increase in perfusion pressure of 70 mmHg over the course of 1 h, significantly enhanced vasoconstrictor responses to sympathetic nerve stimulation for the first 30 min, after which there was no significant enhancement. Responses to noradrenaline were not enhanced by 1 nmol/L endothelin-1. 3. The enhancing effect of low concentrations of endothelin-1 on vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline may play a physiological role in modulating vasomotor function.

在兔离体灌流的去内皮耳动脉中，低浓度的内皮素-1（0.1纳摩尔/升）本身无直接血管收缩作用，但可使去甲肾上腺素和交感神经刺激引起的血管收缩反应缓慢增强。暴露于内皮素-1 60分钟后，增强作用达到最大水平。2. 较高浓度的内皮素-1（1纳摩尔/升）在1小时内使灌流压缓慢升高70毫米汞柱，在最初30分钟内可显著增强对交感神经刺激的血管收缩反应，此后则无显著增强。1纳摩尔/升的内皮素-1对去甲肾上腺素引起的反应无增强作用。3. 低浓度内皮素-1对交感神经刺激和去甲肾上腺素引起的血管收缩反应的增强作用，可能在调节血管运动功能中发挥生理作用。