La M, Rand M J
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.
Eur J Pharmacol. 1993 Nov 9;249(2):133-9. doi: 10.1016/0014-2999(93)90425-h.
Vasoconstrictor responses to ATP were enhanced in a concentration-dependent-manner by endothelin-1 (0.1-1 nM) in isolated perfused segments of rabbit ear artery. Higher concentrations of endothelin-1 (3-10 nM) also enhanced vasoconstrictor responses to ATP. The enhancement of ATP responses by endothelin-1 (0.1-10 nM) was not affected by nicardipine (10 nM). The ATP-mediated component of the vasoconstrictor response to perivascular nerve stimulation in the rabbit jejunal artery was enhanced by endothelin-1 to a similar extent as that to exogenously administered ATP. The enhancement of vasoconstrictor responses to neurogenic ATP was also not affected by nicardipine.
在兔耳动脉离体灌注段中，内皮素 -1（0.1 - 1 nM）以浓度依赖性方式增强了对ATP的血管收缩反应。更高浓度的内皮素 -1（3 - 10 nM）也增强了对ATP的血管收缩反应。内皮素 -1（0.1 - 10 nM）对ATP反应的增强不受尼卡地平（10 nM）的影响。内皮素 -1将兔空肠动脉对血管周围神经刺激的血管收缩反应中由ATP介导的成分增强到与对外源性给予ATP相似的程度。对神经源性ATP的血管收缩反应增强也不受尼卡地平的影响。
