Department of Medicine, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130, USA.
Neurocrit Care. 2010 Oct;13(2):286-94. doi: 10.1007/s12028-010-9386-6.
Continuous renal replacement therapy (CRRT) is a renal replacement modality that is often used in the ICU setting, including the neuro-ICU. This form of renal replacement therapy has been used classically for acute renal failure in patients with hemodynamic compromise, but is gaining acceptance as a method to control vascular and extra-vascular volume and mediate cytokines in non-renal diseases. Although these uses are briefly discussed, this review concentrates on the different forms of continuous renal replacement, mainly focusing on the technology of convective versus diffusive modalities and briefly on filter technology. There is also discussion on the various anticoagulation regimes used in CRRT including data on performing CRRT without anticoagulation. This review is not meant to be a discussion on the pros and cons of CRRT versus intermittent dialysis, but rather a primer on the technology of CRRT and how this therapy may affect general care of the ICU patient.
连续肾脏替代疗法（CRRT）是一种肾脏替代治疗模式，常用于 ICU 环境中，包括神经 ICU。这种肾脏替代治疗方法传统上用于血流动力学不稳定的急性肾衰竭患者，但也越来越被接受为控制血管内外容量和调节非肾脏疾病细胞因子的方法。虽然这些用途简要讨论过，但本综述集中于不同形式的连续肾脏替代治疗，主要侧重于对流和弥散模式的技术，并简要讨论了过滤器技术。还有关于 CRRT 中使用的各种抗凝方案的讨论，包括无需抗凝进行 CRRT 的数据。本综述并非旨在讨论 CRRT 与间歇性透析的优缺点，而是关于 CRRT 技术的介绍，以及这种治疗方法如何影响 ICU 患者的一般治疗。
