Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Eur J Immunol. 2010 Jul;40(7):1873-6. doi: 10.1002/eji.201040707.
After two decades in the shadow of their alphabeta counterparts, gammadelta T cells have recently gathered significant attention following the discovery that they produce IL-17 in various mouse models of infection and autoimmune disease. In contrast, the secretion of large amounts of IFN-gamma by gammadelta T cells has long been known, and has been tightly linked to their anti-tumor function. In this issue of the European Journal of Immunology, a study unexpectedly reports that the lymphoid gammadelta T cells that infiltrate tumor foci induced in the mouse skin produce very little IFN-gamma, but abundant IL-17. In fact, these gammadelta T cells are the major source of IL-17 within the tumor microenvironment, where they appear to promote angiogenesis, and thus tumor growth. This Commentary discusses the relevance of these interesting findings in the context of the currently paradoxical pro- versus anti-tumor roles of IL-17 in cancer immunology.
在经历了二十年的沉寂之后，γδ T 细胞最近在感染和自身免疫性疾病的各种小鼠模型中发现它们能够产生白细胞介素-17（IL-17）后，受到了广泛关注。相比之下，γδ T 细胞大量产生 IFN-γ早已为人所知，并且与它们的抗肿瘤功能密切相关。在本期《欧洲免疫学杂志》中，一项研究出人意料地报告称，在小鼠皮肤中诱导的肿瘤病灶浸润的淋巴样γδ T 细胞几乎不产生 IFN-γ，但会产生大量的白细胞介素-17（IL-17）。事实上，这些 γδ T 细胞是肿瘤微环境中 IL-17 的主要来源，它们似乎促进了血管生成，从而促进了肿瘤的生长。这篇评论文章结合目前癌症免疫学中白细胞介素-17（IL-17）在抗肿瘤和促肿瘤方面存在矛盾的观点，讨论了这些有趣发现的相关性。
